Risk of Never Taking Hormone Replacement Therapy (HRT) During Menopause

Hormone Replacement Therapy (HRT), also known as Menopausal Hormone Therapy (MHT), is used to manage menopausal symptoms and reduce long-term risks such as osteoporosis. This page estimates the potential risks of **not using HRT**, including fracture, cardiovascular disease, cancer, and dementia outcomes.

Your Inputs

Please answer the following questions to generate a personalized estimate.

How many years have you gone without HRT? This affects the degree of bone loss and fracture risk. [{"label":"7.1\u202fyears\u202f\u2013\u202festrogen\u2011only HRT ","withHRT":" 92\u2013113 ","withoutHRT":" 141"},{"label":"5.6\u202fyears\u202f\u2013\u202fcombined HRT ","withHRT":" 79\u201396 ","withoutHRT":" 111"}]

What are the cardiovascular and clotting risks without HRT? Includes CHD, stroke, and venous thromboembolism (VTE). [{"condition":"Coronary heart disease ","withHRT":" 157 ","withoutHRT":" 132"},{"condition":"Stroke ","withHRT":" 44 ","withoutHRT":" 32"},{"condition":"Venous thromboembolism (VTE) ","withHRT":" 34 ","withoutHRT":" 16"}]

What is your cancer-related risk profile? Includes breast, ovarian, and endometrial cancer outcomes. [{"cancerType":"Breast Cancer (combined HRT) ","withHRT":" +9 to +36 per 10,000 ","withoutHRT":" baseline varies"},{"cancerType":"Ovarian Cancer ","withHRT":" ~1 per 1,000 ","withoutHRT":" baseline varies"},{"cancerType":"Endometrial Cancer (combined HRT) ","withHRT":" reduced\/neutral ","withoutHRT":" baseline varies"}]

Are you 65 or older and concerned about dementia risk? Data suggests a small increased dementia risk when HRT is started after age 65. [{"scenario":"Women \u226565, combined HRT ","withHRT":" 11 ","withoutHRT":" 9"}]

Your Results

Fracture Risk Reduction from HRT:

Cardiovascular Risk Increases with HRT: riskdisplay: can't find riskmodel named CardiovascularRiskModel

Cancer Risk Increases with HRT:

Dementia Risk Increase with HRT (Age ≥65):

See the data page for full tables, sources, and model formulas.

Generated by an AI assistant.