View source for RiskofNeverTakingHRT/Data

= Data for RiskOfNeverTakingHRTForMenopause =

== Fracture Risk Data ==
<datatable2 table="FractureRiskTable" columns="label|withHRT|withoutHRT">
<head>
! Scenario (for dropdown)
! Fractures with HRT (per 1000)
! Fractures without HRT (per 1000)
</head>
7.1 years – estrogen‑only HRT | 92–113 | 141
5.6 years – combined HRT       | 79–96  | 111
</datatable2>

*Explanation:*  
Women on HRT had fewer fractures than those not taking it—for both estrogen-only and combined regimens.  
- Source: [PubMed – WHI WHR Study](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com)

<RiskModel name="FractureRiskModel" calculation="withoutHRT - withHRT">
label = label
withHRT = withHRT
withoutHRT = withoutHRT
</RiskModel>

== Cardiovascular, Stroke, and VTE Risk Data ==
<datatable2 table="CardiovascularRiskTable" columns="condition|withHRT|withoutHRT">
<head>
! Condition (for dropdown)
! Incidence with HRT (per 10,000)
! Incidence without HRT (per 10,000)
</head>
Coronary heart disease         | 157 | 132
Stroke                          | 44  | 32
Venous thromboembolism (VTE)   | 34  | 16
</datatable2>

*Explanation:*  
Combined HRT is associated with slightly higher incidence of CHD, stroke, and VTE.  
- Source: [CMAJ WHI Summary](https://www.cmaj.ca/content/170/10/1535?utm_source=chatgpt.com)

<RiskModel name="CHDRiskModel" calculation="withHRT - withoutHRT">
condition = 'Coronary heart disease'
withHRT = withHRT
withoutHRT = withoutHRT
</RiskModel>

<RiskModel name="StrokeRiskModel" calculation="withHRT - withoutHRT">
condition = 'Stroke'
withHRT = withHRT
withoutHRT = withoutHRT
</RiskModel>

<RiskModel name="VTERiskModel" calculation="withHRT - withoutHRT">
condition = 'Venous thromboembolism (VTE)'
withHRT = withHRT
withoutHRT = withoutHRT
</RiskModel>

== Cancer Risk Data ==
<datatable2 table="CancerRiskTable" columns="cancerType|withHRT|withoutHRT">
<head>
! Cancer Type (for dropdown)
! Incidence with HRT (per women-years)
! Baseline without HRT
</head>
Breast Cancer (combined HRT) | +9 to +36 per 10,000 | baseline varies
Ovarian Cancer               | ~1 per 1,000         | baseline varies
Endometrial Cancer (combined HRT) | reduced/neutral | baseline varies
</datatable2>

*Explanation:*  
Combined HRT may increase breast and ovarian cancer risk, but appears neutral or protective for endometrial cancer.  
- Sources:  
  - [Menopause.org.au Breast Cancer](https://www.menopause.org.au/members/ims-menopause-live/use-of-hormone-replacement-therapy-hrt-and-risk-of-breast-cancer?utm_source=chatgpt.com)  
  - [SAGE Journal Analysis](https://journals.sagepub.com/doi/10.1177/2053369120957514?utm_source=chatgpt.com)

<RiskModel name="BreastCancerRiskModel" calculation="withHRT">
cancerType = 'Breast Cancer (combined HRT)'
withHRT = withHRT
</RiskModel>

<RiskModel name="OvarianCancerRiskModel" calculation="withHRT">
cancerType = 'Ovarian Cancer'
withHRT = withHRT
</RiskModel>

== Dementia Risk Data ==
<datatable2 table="DementiaRiskTable" columns="scenario|withHRT|withoutHRT">
<head>
! Scenario (for dropdown)
! Dementia incidence with HRT (per 1000)
! Dementia incidence without HRT (per 1000)
</head>
Women ≥65, combined HRT | 11 | 9
</datatable2>

*Explanation:*  
In women aged 65+, combined HRT is tied to slightly higher dementia risk.  
- Source: [WHI Memory Study – PubMed](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com)

<RiskModel name="DementiaRiskModel" calculation="withHRT - withoutHRT">
scenario = 'Women ≥65, combined HRT'
withHRT = withHRT
withoutHRT = withoutHRT
</RiskModel>

== Uncertainty Note ==
These figures represent population averages and may not apply to every individual due to variables like geography, age at menopause, HRT type, and personal health.

Generated by an AI assistant.