Data for RiskOfNeverTakingHRTForMenopause

Fracture Risk Data

Scenario (for dropdown)	Fractures with HRT (per 1000)	Fractures without HRT (per 1000)
7.1 years – estrogen‑only HRT	92–113	141
5.6 years – combined HRT	79–96	111

Explanation:*

Women on HRT had fewer fractures than those not taking it—for both estrogen-only and combined regimens. - Source: [PubMed – WHI WHR Study](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com)

  RiskModel: RiskofNeverTakingHRT/Data:FractureRiskModel
    Content: 
label = label
withHRT = withHRT
withoutHRT = withoutHRT

Cardiovascular, Stroke, and VTE Risk Data

Condition (for dropdown)	Incidence with HRT (per 10,000)	Incidence without HRT (per 10,000)
Coronary heart disease	157	132
Stroke	44	32
Venous thromboembolism (VTE)	34	16

Explanation:*

Combined HRT is associated with slightly higher incidence of CHD, stroke, and VTE. - Source: [CMAJ WHI Summary](https://www.cmaj.ca/content/170/10/1535?utm_source=chatgpt.com)

  RiskModel: RiskofNeverTakingHRT/Data:CHDRiskModel
    Content: 
condition = 'Coronary heart disease'
withHRT = withHRT
withoutHRT = withoutHRT

  RiskModel: RiskofNeverTakingHRT/Data:StrokeRiskModel
    Content: 
condition = 'Stroke'
withHRT = withHRT
withoutHRT = withoutHRT

  RiskModel: RiskofNeverTakingHRT/Data:VTERiskModel
    Content: 
condition = 'Venous thromboembolism (VTE)'
withHRT = withHRT
withoutHRT = withoutHRT

Cancer Risk Data

Cancer Type (for dropdown)	Incidence with HRT (per women-years)	Baseline without HRT
Breast Cancer (combined HRT)	+9 to +36 per 10,000	baseline varies
Ovarian Cancer	~1 per 1,000	baseline varies
Endometrial Cancer (combined HRT)	reduced/neutral	baseline varies

Explanation:*

Combined HRT may increase breast and ovarian cancer risk, but appears neutral or protective for endometrial cancer. - Sources:

 - [Menopause.org.au Breast Cancer](https://www.menopause.org.au/members/ims-menopause-live/use-of-hormone-replacement-therapy-hrt-and-risk-of-breast-cancer?utm_source=chatgpt.com)  
 - [SAGE Journal Analysis](https://journals.sagepub.com/doi/10.1177/2053369120957514?utm_source=chatgpt.com)

  RiskModel: RiskofNeverTakingHRT/Data:BreastCancerRiskModel
    Content: 
cancerType = 'Breast Cancer (combined HRT)'
withHRT = withHRT

  RiskModel: RiskofNeverTakingHRT/Data:OvarianCancerRiskModel
    Content: 
cancerType = 'Ovarian Cancer'
withHRT = withHRT

Dementia Risk Data

Scenario (for dropdown)	Dementia incidence with HRT (per 1000)	Dementia incidence without HRT (per 1000)
Women ≥65, combined HRT	11	9

Explanation:*

In women aged 65+, combined HRT is tied to slightly higher dementia risk. - Source: [WHI Memory Study – PubMed](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com)

  RiskModel: RiskofNeverTakingHRT/Data:DementiaRiskModel
    Content: 
scenario = 'Women ≥65, combined HRT'
withHRT = withHRT
withoutHRT = withoutHRT

Uncertainty Note

These figures represent population averages and may not apply to every individual due to variables like geography, age at menopause, HRT type, and personal health.

Generated by an AI assistant.