RiskofNeverTakingHRT/Data: Difference between revisions
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Risk of Never Taking HRT For Menopause / Data |
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RiskOfNeverTakingHRTForMenopause/Data | |||
1. Bone Fracture Risk | |||
<datatable2 name="FractureRiskTable"> <head> ColumnAgeGroup | ColumnFractureWithHRT | ColumnFractureWithoutHRT </head> <row> “7.1 years—oestrogen-only: 92–113 per 1000; placebo: 141 per 1000” </row> <row> “5.6 years—combined HT: 79–96 per 1000; placebo: 111 per 1000” </row> </datatable2> | |||
Explanation: | |||
This table shows observed clinical fracture incidence in women using HRT versus those not using it, from trial data. Studies show that estrogen-only HRT reduced fractures from ~141 to between 92–113 per 1,000, and combined HRT reduced from ~111 to between 79–96 per 1,000. | |||
Source: | |||
PubMed | |||
< RiskModel FractureReductionModel> | |||
RiskWithoutHRT = ColumnFractureWithoutHRT | |||
RiskWithHRT = ColumnFractureWithHRT | |||
RiskDifference = RiskWithoutHRT – RiskWithHRT | |||
</RiskModel> | |||
2. Cardiovascular, Stroke, and Thrombosis Risks | |||
<datatable2 name="CardiovascularRiskTable"> <head> ColumnCondition | ColumnWithHRT | ColumnWithoutHRT </head> <row> “Coronary heart disease: 37 vs 30 per 10,000 per year” </row> <row> “Stroke: 29 vs 21 per 10,000 per year” </row> <row> “Blood clots (total VTE): 34 vs 16 per 10,000 per year” </row> </datatable2> | |||
Explanation: | |||
Combined HRT was associated with slightly higher incidence of coronary heart disease, stroke, and venous thromboembolism compared to those without HRT (per 10,000 women per year). | |||
Source: | |||
Government of Canada | |||
< RiskModel CardiovascularModel> | |||
RiskWithoutHRT_CHD = ColumnWithoutHRT (CHD) | |||
RiskWithHRT_CHD = ColumnWithHRT (CHD) | |||
... similarly for stroke and VTE. | |||
</RiskModel> | |||
3. Cancer Risks | |||
<datatable2 name="CancerRiskTable"> <head> ColumnCancerType | ColumnWithHRT | ColumnWithoutHRT </head> <row> “Breast cancer (combined E+P): 9‑36 extra cases per 10,000 women‑years” </row> <row> “Ovarian cancer: ~1 extra per 1000 users (≈1 per 5000 women‑years)” </row> <row> “Endometrial cancer: neutral or possible reduction with combined HRT” </row> </datatable2> | |||
Explanation: | |||
Long-term combined HRT may produce between 9 to 36 additional breast cancer cases per 10,000 women-years. Ovarian cancer risk is modestly elevated (~1 extra per 1,000 users, equating to 1 per 5,000 per year), while combined HRT may not increase—and may lower—endometrial cancer risk. | |||
Sources: | |||
menopause.org.au | |||
SAGE Journals | |||
Government of Canada | |||
< RiskModel CancerModel> | |||
BreastRiskWithoutHRT = baseline (not in table) | |||
BreastRiskWithHRT = BreastRiskWithoutHRT + ColumnWithHRT (breast) | |||
… similarly for ovarian, endometrial. | |||
</RiskModel> | |||
4. All‑Cause Mortality & Dementia (older women) | |||
<datatable2 name="MortalityDementiaRiskTable"> <head> ColumnOutcome | ColumnWithHRT | ColumnWithoutHRT </head> <row> “Dementia (≥65 yrs, combined HRT): 45 vs 22 per 10,000 per year” </row> </datatable2> | |||
Explanation: | |||
In women aged 65 or older, combined HRT was associated with an additional ~23 dementia cases per 10,000 women per year compared to non-use. | |||
Source: | |||
Government of Canada | |||
< RiskModel DementiaModel> | |||
RiskWithoutHRT = ColumnWithoutHRT | |||
RiskWithHRT = ColumnWithHRT | |||
Difference = RiskWithHRT – RiskWithoutHRT | |||
</RiskModel> | |||
Uncertainty Note | |||
Risks and risk reductions are based on averages across populations. Individual outcomes can vary greatly according to personal health status, timing relative to menopause onset, formulation and dosage of HRT, and geographic or demographic factors. | |||
Generated by an AI assistant. | |||
Revision as of 00:06, 8 September 2025
RiskOfNeverTakingHRTForMenopause/Data 1. Bone Fracture Risk <datatable2 name="FractureRiskTable"> <head> ColumnAgeGroup | ColumnFractureWithHRT | ColumnFractureWithoutHRT </head> <row> “7.1 years—oestrogen-only: 92–113 per 1000; placebo: 141 per 1000” </row> <row> “5.6 years—combined HT: 79–96 per 1000; placebo: 111 per 1000” </row> </datatable2>
Explanation: This table shows observed clinical fracture incidence in women using HRT versus those not using it, from trial data. Studies show that estrogen-only HRT reduced fractures from ~141 to between 92–113 per 1,000, and combined HRT reduced from ~111 to between 79–96 per 1,000.
Source: PubMed
< RiskModel FractureReductionModel> RiskWithoutHRT = ColumnFractureWithoutHRT RiskWithHRT = ColumnFractureWithHRT RiskDifference = RiskWithoutHRT – RiskWithHRT </RiskModel>
2. Cardiovascular, Stroke, and Thrombosis Risks <datatable2 name="CardiovascularRiskTable"> <head> ColumnCondition | ColumnWithHRT | ColumnWithoutHRT </head> <row> “Coronary heart disease: 37 vs 30 per 10,000 per year” </row> <row> “Stroke: 29 vs 21 per 10,000 per year” </row> <row> “Blood clots (total VTE): 34 vs 16 per 10,000 per year” </row> </datatable2>
Explanation: Combined HRT was associated with slightly higher incidence of coronary heart disease, stroke, and venous thromboembolism compared to those without HRT (per 10,000 women per year).
Source: Government of Canada
< RiskModel CardiovascularModel> RiskWithoutHRT_CHD = ColumnWithoutHRT (CHD) RiskWithHRT_CHD = ColumnWithHRT (CHD) ... similarly for stroke and VTE. </RiskModel>
3. Cancer Risks <datatable2 name="CancerRiskTable"> <head> ColumnCancerType | ColumnWithHRT | ColumnWithoutHRT </head> <row> “Breast cancer (combined E+P): 9‑36 extra cases per 10,000 women‑years” </row> <row> “Ovarian cancer: ~1 extra per 1000 users (≈1 per 5000 women‑years)” </row> <row> “Endometrial cancer: neutral or possible reduction with combined HRT” </row> </datatable2>
Explanation: Long-term combined HRT may produce between 9 to 36 additional breast cancer cases per 10,000 women-years. Ovarian cancer risk is modestly elevated (~1 extra per 1,000 users, equating to 1 per 5,000 per year), while combined HRT may not increase—and may lower—endometrial cancer risk.
Sources: menopause.org.au SAGE Journals Government of Canada
< RiskModel CancerModel> BreastRiskWithoutHRT = baseline (not in table) BreastRiskWithHRT = BreastRiskWithoutHRT + ColumnWithHRT (breast) … similarly for ovarian, endometrial. </RiskModel>
4. All‑Cause Mortality & Dementia (older women) <datatable2 name="MortalityDementiaRiskTable"> <head> ColumnOutcome | ColumnWithHRT | ColumnWithoutHRT </head> <row> “Dementia (≥65 yrs, combined HRT): 45 vs 22 per 10,000 per year” </row> </datatable2>
Explanation: In women aged 65 or older, combined HRT was associated with an additional ~23 dementia cases per 10,000 women per year compared to non-use.
Source: Government of Canada
< RiskModel DementiaModel> RiskWithoutHRT = ColumnWithoutHRT RiskWithHRT = ColumnWithHRT Difference = RiskWithHRT – RiskWithoutHRT </RiskModel>
Uncertainty Note
Risks and risk reductions are based on averages across populations. Individual outcomes can vary greatly according to personal health status, timing relative to menopause onset, formulation and dosage of HRT, and geographic or demographic factors.
Generated by an AI assistant.