Latest revision as of 00:16, 8 September 2025

Risk of Never Taking Hormone Replacement Therapy (HRT) During Menopause

Hormone Replacement Therapy (HRT), also known as Menopausal Hormone Therapy (MHT), is used to manage menopausal symptoms and reduce long-term risks such as osteoporosis. This page estimates the potential risks of **not using HRT**, including fracture, cardiovascular disease, cancer, and dementia outcomes.

Your Inputs

Please answer the following questions to generate a personalized estimate.

How many years have you gone without HRT? This affects the degree of bone loss and fracture risk. [{"label":"7.1\u202fyears\u202f\u2013\u202festrogen\u2011only HRT ","withHRT":" 92\u2013113 ","withoutHRT":" 141"},{"label":"5.6\u202fyears\u202f\u2013\u202fcombined HRT ","withHRT":" 79\u201396 ","withoutHRT":" 111"}]

What are the cardiovascular and clotting risks without HRT? Includes CHD, stroke, and venous thromboembolism (VTE). [{"condition":"Coronary heart disease ","withHRT":" 157 ","withoutHRT":" 132"},{"condition":"Stroke ","withHRT":" 44 ","withoutHRT":" 32"},{"condition":"Venous thromboembolism (VTE) ","withHRT":" 34 ","withoutHRT":" 16"}]

What is your cancer-related risk profile? Includes breast, ovarian, and endometrial cancer outcomes. [{"cancerType":"Breast Cancer (combined HRT) ","withHRT":" +9 to +36 per 10,000 ","withoutHRT":" baseline varies"},{"cancerType":"Ovarian Cancer ","withHRT":" ~1 per 1,000 ","withoutHRT":" baseline varies"},{"cancerType":"Endometrial Cancer (combined HRT) ","withHRT":" reduced\/neutral ","withoutHRT":" baseline varies"}]

Are you 65 or older and concerned about dementia risk? Data suggests a small increased dementia risk when HRT is started after age 65. [{"scenario":"Women \u226565, combined HRT ","withHRT":" 11 ","withoutHRT":" 9"}]

Your Results

Fracture Risk Reduction from HRT:

Cardiovascular Risk Increases with HRT: riskdisplay: can't find riskmodel named CardiovascularRiskModel

Cancer Risk Increases with HRT:

Dementia Risk Increase with HRT (Age ≥65):

See the data page for full tables, sources, and model formulas.

Generated by an AI assistant.

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-RiskOfNeverTakingHRTForMenopause
-Heading
-Risk of Never Taking Hormone Replacement Therapy (HRT) During Menopause
+= Risk of Never Taking Hormone Replacement Therapy (HRT) During Menopause =
-Introduction
+Hormone Replacement Therapy (HRT), also known as Menopausal Hormone Therapy (MHT), is used to manage menopausal symptoms and reduce long-term risks such as osteoporosis. This page estimates the potential risks of **not using HRT**, including fracture, cardiovascular disease, cancer, and dementia outcomes.
-Hormone Replacement Therapy (HRT), also known as Menopausal Hormone Therapy (MHT), is often used to manage menopausal symptoms and mitigate long-term health risks. This risk calculator estimates what may happen if no HRT is taken—highlighting potential increases in osteoporosis, fracture rates, cardiovascular outcomes, and other health impacts.
-Your Inputs
+== Your Inputs ==
-Below are key factors that influence the risk. Please select an option for each:
+Please answer the following questions to generate a personalized estimate.
-Age at Menopause (earlier menopause may elevate risk of osteoporosis and certain cancers)
+'''How many years have you gone without HRT?'''
-<DropDown name="AgeAtMenopause">
+This affects the degree of bone loss and fracture risk.
+<DropDown name="FractureDuration" table="FractureRiskTable" />
-Duration Without HRT (time since menopause without therapy—baseline exposure period)
+'''What are the cardiovascular and clotting risks without HRT?'''
-<DropDown name="YearsWithoutHRT">
+Includes CHD, stroke, and venous thromboembolism (VTE).
+<DropDown name="CardioCondition" table="CardiovascularRiskTable" />
-Bone Fracture Risk (risk of hip or clinical fracture per 1,000 women)
+'''What is your cancer-related risk profile?'''
-<DropDown name="FractureRisk">
+Includes breast, ovarian, and endometrial cancer outcomes.
+<DropDown name="CancerType" table="CancerRiskTable" />
-Cardiovascular/Stroke/VTE Risk (risks per 1,000 or 10,000 women)
+'''Are you 65 or older and concerned about dementia risk?'''
-<DropDown name="CardiovascularRisk">
+Data suggests a small increased dementia risk when HRT is started after age 65.
+<DropDown name="DementiaScenario" table="DementiaRiskTable" />
-Cancer Risk (e.g., breast, ovarian, endometrial risk per women-years)
+== Your Results ==
-<DropDown name="CancerRisk">
-Your Results
+'''Fracture Risk Reduction from HRT:'''
+<RiskDisplay model="FractureRiskModel" />
-< RiskDisplay model="RiskModel_Fracture" />
+'''Cardiovascular Risk Increases with HRT:'''
+<RiskDisplay model="CardiovascularRiskModel" />
+<RiskDisplay model="StrokeRiskModel" />
+<RiskDisplay model="VTERiskModel" />
-< RiskDisplay model="RiskModel_Cardiovascular" />
+'''Cancer Risk Increases with HRT:'''
+<RiskDisplay model="BreastCancerRiskModel" />
+<RiskDisplay model="OvarianCancerRiskModel" />
-< RiskDisplay model="RiskModel_Cancer" />
+'''Dementia Risk Increase with HRT (Age ≥65):'''
+<RiskDisplay model="DementiaRiskModel" />
-See the [[RiskOfNeverTakingHRTForMenopause/Data|data subpage]] for detailed tables of inputs, sources, and calculation methods.
+See the [[RiskOfNeverTakingHRTForMenopause/Data|data page]] for full tables, sources, and model formulas.
 Generated by an AI assistant.