Latest revision as of 00:16, 8 September 2025

Risk of Never Taking Hormone Replacement Therapy (HRT) During Menopause

Hormone Replacement Therapy (HRT), also known as Menopausal Hormone Therapy (MHT), is used to manage menopausal symptoms and reduce long-term risks such as osteoporosis. This page estimates the potential risks of **not using HRT**, including fracture, cardiovascular disease, cancer, and dementia outcomes.

Your Inputs

Please answer the following questions to generate a personalized estimate.

How many years have you gone without HRT? This affects the degree of bone loss and fracture risk. [{"label":"7.1\u202fyears\u202f\u2013\u202festrogen\u2011only HRT ","withHRT":" 92\u2013113 ","withoutHRT":" 141"},{"label":"5.6\u202fyears\u202f\u2013\u202fcombined HRT ","withHRT":" 79\u201396 ","withoutHRT":" 111"}]

What are the cardiovascular and clotting risks without HRT? Includes CHD, stroke, and venous thromboembolism (VTE). [{"condition":"Coronary heart disease ","withHRT":" 157 ","withoutHRT":" 132"},{"condition":"Stroke ","withHRT":" 44 ","withoutHRT":" 32"},{"condition":"Venous thromboembolism (VTE) ","withHRT":" 34 ","withoutHRT":" 16"}]

What is your cancer-related risk profile? Includes breast, ovarian, and endometrial cancer outcomes. [{"cancerType":"Breast Cancer (combined HRT) ","withHRT":" +9 to +36 per 10,000 ","withoutHRT":" baseline varies"},{"cancerType":"Ovarian Cancer ","withHRT":" ~1 per 1,000 ","withoutHRT":" baseline varies"},{"cancerType":"Endometrial Cancer (combined HRT) ","withHRT":" reduced\/neutral ","withoutHRT":" baseline varies"}]

Are you 65 or older and concerned about dementia risk? Data suggests a small increased dementia risk when HRT is started after age 65. [{"scenario":"Women \u226565, combined HRT ","withHRT":" 11 ","withoutHRT":" 9"}]

Your Results

Fracture Risk Reduction from HRT:

Cardiovascular Risk Increases with HRT: riskdisplay: can't find riskmodel named CardiovascularRiskModel

Cancer Risk Increases with HRT:

Dementia Risk Increase with HRT (Age ≥65):

See the data page for full tables, sources, and model formulas.

Generated by an AI assistant.

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 = Risk of Never Taking Hormone Replacement Therapy (HRT) During Menopause =
-Hormone Replacement Therapy (HRT), also known as Menopausal Hormone Therapy (MHT), is used to manage menopausal symptoms and reduce certain long-term health risks. This page helps estimate the **risk associated with not using HRT** — specifically in areas like fracture risk, cardiovascular disease, dementia, and cancer.
+Hormone Replacement Therapy (HRT), also known as Menopausal Hormone Therapy (MHT), is used to manage menopausal symptoms and reduce long-term risks such as osteoporosis. This page estimates the potential risks of **not using HRT**, including fracture, cardiovascular disease, cancer, and dementia outcomes.
 == Your Inputs ==
-Please answer the questions below to estimate your relative risks if no HRT is taken.
+Please answer the following questions to generate a personalized estimate.
 '''How many years have you gone without HRT?'''
-This affects how much exposure your body has had to lower estrogen levels post-menopause, which can increase risks such as bone fracture.
+This affects the degree of bone loss and fracture risk.
-<DropDown name="FractureRiskTable">
+<DropDown name="FractureDuration" table="FractureRiskTable" />
-'''What is your cardiovascular and blood clot risk without HRT?'''
+'''What are the cardiovascular and clotting risks without HRT?'''
-These outcomes include coronary heart disease, stroke, and venous thromboembolism (VTE).
+Includes CHD, stroke, and venous thromboembolism (VTE).
-<DropDown name="CardiovascularRiskTable">
+<DropDown name="CardioCondition" table="CardiovascularRiskTable" />
-'''What is your estimated cancer risk without HRT?'''
+'''What is your cancer-related risk profile?'''
-This includes potential increases in breast and ovarian cancer from taking (or not taking) hormone therapy.
+Includes breast, ovarian, and endometrial cancer outcomes.
-<DropDown name="CancerRiskTable">
+<DropDown name="CancerType" table="CancerRiskTable" />
 '''Are you 65 or older and concerned about dementia risk?'''
-Some studies show that starting HRT late (after 65) may be linked to increased dementia risk.
+Data suggests a small increased dementia risk when HRT is started after age 65.
-<DropDown name="DementiaRiskTable">
+<DropDown name="DementiaScenario" table="DementiaRiskTable" />
 == Your Results ==
-Below are estimated changes in outcomes related to **not taking HRT**:
+'''Fracture Risk Reduction from HRT:'''
-'''Fracture Risk Difference'''
 <RiskDisplay model="FractureRiskModel" />
-'''Cardiovascular Risk Differences'''
+'''Cardiovascular Risk Increases with HRT:'''
 <RiskDisplay model="CardiovascularRiskModel" />
 <RiskDisplay model="StrokeRiskModel" />
 <RiskDisplay model="VTERiskModel" />
-'''Cancer Risk Differences'''
+'''Cancer Risk Increases with HRT:'''
 <RiskDisplay model="BreastCancerRiskModel" />
 <RiskDisplay model="OvarianCancerRiskModel" />
-'''Dementia Risk Difference (Age ≥65)'''
+'''Dementia Risk Increase with HRT (Age ≥65):'''
 <RiskDisplay model="DementiaRiskModel" />
-See the [[RiskOfNeverTakingHRTForMenopause/Data|data page]] for complete data sources, tables, and calculations.
+See the [[RiskOfNeverTakingHRTForMenopause/Data|data page]] for full tables, sources, and model formulas.
 Generated by an AI assistant.