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Risk of Never Taking HRT for Menopause / Data
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Risk of Never Taking HRT for Menopause / Data
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= Data for RiskOfNeverTakingHRTForMenopause =
= Data for RiskOfNeverTakingHRTForMenopause =


== Fracture Data ==
== Fracture Risk Data ==
<datatable2 name="FractureRiskTable">
<datatable2 name="FractureRiskTable">
<head>
<head>
ColumnDuration | ColumnFractureWithHRT | ColumnFractureWithoutHRT
Fracture_Label | Fracture_WithHRT | Fracture_WithoutHRT
</head>
</head>
<row>
<row>
7.1 years—oestrogen-only | 92–113 per 1000 | 141 per 1000
7.1 years – estrogen-only HRT | 92–113 per 1000 | 141 per 1000
</row>
</row>
<row>
<row>
5.6 years—combined HRT | 79–96 per 1000 | 111 per 1000
5.6 years – combined HRT | 79–96 per 1000 | 111 per 1000
</row>
</row>
</datatable2>
</datatable2>


*Explanation:*   
*Explanation:*   
Long-term HRT—either estrogen-only or combined—was associated with lower fracture incidence compared to placebo.   
Women taking HRT had significantly lower fracture rates than those who did not, across both estrogen-only and combined regimens.   
- Source: [PubMed](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com)
- Source: [PubMed – WHI Analysis](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com)


<RiskModel name="FractureRiskModel" calculation="FractureWithoutHRT - FractureWithHRT">
<RiskModel name="FractureRiskModel" calculation="Fracture_WithoutHRT - Fracture_WithHRT">
FractureWithoutHRT = ColumnFractureWithoutHRT  
Fracture_WithoutHRT = Fracture_WithoutHRT  
FractureWithHRT = ColumnFractureWithHRT  
Fracture_WithHRT = Fracture_WithHRT  
</RiskModel>
</RiskModel>


== Cardiovascular, Stroke, and VTE Data ==
== Cardiovascular, Stroke, and VTE Risk ==
<datatable2 name="CardiovascularRiskTable">
<datatable2 name="CardiovascularRiskTable">
<head>
<head>
ColumnCondition | ColumnWithHRT | ColumnWithoutHRT
Cardio_Label | Cardio_WithHRT | Cardio_WithoutHRT
</head>
</head>
<row>
<row>
Line 40: Line 40:


*Explanation:*   
*Explanation:*   
Estrogen-progestin therapy slightly increases cardiovascular risks, according to WHI data.   
Combined HRT was associated with small increases in cardiovascular events.   
- Source: [CMAJ](https://www.cmaj.ca/content/170/10/1535?utm_source=chatgpt.com)
- Source: [CMAJ Review](https://www.cmaj.ca/content/170/10/1535?utm_source=chatgpt.com)


<RiskModel name="CardiovascularRiskModel" calculation="CHD_WithHRT - CHD_WithoutHRT">
<RiskModel name="CardiovascularRiskModel" calculation="Cardio_WithHRT - Cardio_WithoutHRT">
CHD_WithHRT = ColumnWithHRT[Coronary heart disease]   
Cardio_WithHRT = Cardio_WithHRT[Coronary heart disease]   
CHD_WithoutHRT = ColumnWithoutHRT[Coronary heart disease]   
Cardio_WithoutHRT = Cardio_WithoutHRT[Coronary heart disease]   
</RiskModel>
</RiskModel>


<RiskModel name="StrokeRiskModel" calculation="Stroke_WithHRT - Stroke_WithoutHRT">
<RiskModel name="StrokeRiskModel" calculation="Cardio_WithHRT - Cardio_WithoutHRT">
Stroke_WithHRT = ColumnWithHRT[Stroke]   
Cardio_WithHRT = Cardio_WithHRT[Stroke]   
Stroke_WithoutHRT = ColumnWithoutHRT[Stroke]   
Cardio_WithoutHRT = Cardio_WithoutHRT[Stroke]   
</RiskModel>
</RiskModel>


<RiskModel name="VTERiskModel" calculation="VTE_WithHRT - VTE_WithoutHRT">
<RiskModel name="VTERiskModel" calculation="Cardio_WithHRT - Cardio_WithoutHRT">
VTE_WithHRT = ColumnWithHRT[Venous thromboembolism (VTE)]   
Cardio_WithHRT = Cardio_WithHRT[Venous thromboembolism (VTE)]   
VTE_WithoutHRT = ColumnWithoutHRT[Venous thromboembolism (VTE)]   
Cardio_WithoutHRT = Cardio_WithoutHRT[Venous thromboembolism (VTE)]   
</RiskModel>
</RiskModel>


Line 61: Line 61:
<datatable2 name="CancerRiskTable">
<datatable2 name="CancerRiskTable">
<head>
<head>
ColumnCancerType | ColumnWithHRT | ColumnWithoutHRT
Cancer_Label | Cancer_WithHRT | Cancer_WithoutHRT
</head>
</head>
<row>
<row>
Breast Cancer (combined E+P) | +9 to +36 per 10,000 women-years | Baseline varies
Breast Cancer (combined HRT) | +9 to +36 per 10,000 | baseline varies
</row>
</row>
<row>
<row>
Ovarian Cancer | ~1 extra per 1,000 users | Baseline varies
Ovarian Cancer | ~1 extra per 1,000 users | baseline varies
</row>
</row>
<row>
<row>
Endometrial Cancer | Neutral or ↓ with combined HRT | Baseline varies
Endometrial Cancer (combined HRT) | reduced or neutral | baseline varies
</row>
</row>
</datatable2>
</datatable2>


*Explanation:*   
*Explanation:*   
HRT, particularly combined estrogen-progestin, is associated with increased risk of certain cancers.   
Breast and ovarian cancer risks are slightly increased with HRT use. Combined HRT may reduce endometrial cancer risk.   
- Sources:   
- Sources:   
   - [Menopause.org.au](https://www.menopause.org.au/members/ims-menopause-live/use-of-hormone-replacement-therapy-hrt-and-risk-of-breast-cancer?utm_source=chatgpt.com)   
   - [Menopause.org.au](https://www.menopause.org.au/members/ims-menopause-live/use-of-hormone-replacement-therapy-hrt-and-risk-of-breast-cancer?utm_source=chatgpt.com)   
   - [SAGE Journals](https://journals.sagepub.com/doi/10.1177/2053369120957514?utm_source=chatgpt.com)
   - [SAGE Review](https://journals.sagepub.com/doi/10.1177/2053369120957514?utm_source=chatgpt.com)


<RiskModel name="BreastCancerRiskModel" calculation="BaselineRisk + BreastCancer_WithHRT_Extra">
<RiskModel name="BreastCancerRiskModel" calculation="Cancer_WithHRT">
BaselineRisk = placeholder 
Cancer_WithHRT = Cancer_WithHRT[Breast Cancer (combined HRT)]   
BreastCancer_WithHRT_Extra = ColumnWithHRT[Breast Cancer (combined E+P)]   
</RiskModel>
</RiskModel>


<RiskModel name="OvarianCancerRiskModel" calculation="BaselineRisk + OvarianCancer_WithHRT_Extra">
<RiskModel name="OvarianCancerRiskModel" calculation="Cancer_WithHRT">
BaselineRisk = placeholder 
Cancer_WithHRT = Cancer_WithHRT[Ovarian Cancer]   
OvarianCancer_WithHRT_Extra = ColumnWithHRT[Ovarian Cancer]   
</RiskModel>
</RiskModel>


== Dementia Data ==
== Dementia Risk (Age ≥65) ==
<datatable2 name="DementiaRiskTable">
<datatable2 name="DementiaRiskTable">
<head>
<head>
ColumnOutcome | ColumnWithHRT | ColumnWithoutHRT
Dementia_Label | Dementia_WithHRT | Dementia_WithoutHRT
</head>
</head>
<row>
<row>
Dementia in women ≥65 yrs (combined HRT) | 11 per 1000 | 9 per 1000
Women ≥65 using combined HRT | 11 per 1,000 | 9 per 1,000
</row>
</row>
</datatable2>
</datatable2>


*Explanation:*   
*Explanation:*   
In women aged 65 and older, dementia risk was slightly higher in those on HRT.   
HRT started in older age (≥65) may slightly raise the risk of dementia.   
- Source: [PubMed](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com)
- Source: [WHI Memory Study – PubMed](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com)


<RiskModel name="DementiaRiskModel" calculation="Dementia_WithHRT - Dementia_WithoutHRT">
<RiskModel name="DementiaRiskModel" calculation="Dementia_WithHRT - Dementia_WithoutHRT">
Dementia_WithHRT = ColumnWithHRT[Dementia in women ≥65 yrs (combined HRT)]  
Dementia_WithHRT = Dementia_WithHRT  
Dementia_WithoutHRT = ColumnWithoutHRT[Dementia in women ≥65 yrs (combined HRT)]  
Dementia_WithoutHRT = Dementia_WithoutHRT  
</RiskModel>
</RiskModel>


== Uncertainty Note ==
== Uncertainty Note ==
Risks are based on population averages and may vary significantly by age, health status, geography, and timing of HRT initiation.
Risk estimates are population-level averages and may vary based on age, timing of HRT, genetics, and other personal health factors.


Generated by an AI assistant.
Generated by an AI assistant.

Revision as of 00:19, 8 September 2025

Data for RiskOfNeverTakingHRTForMenopause

Fracture Risk Data

<datatable2 name="FractureRiskTable"> <head> Fracture_Label | Fracture_WithHRT | Fracture_WithoutHRT </head> <row> 7.1 years – estrogen-only HRT | 92–113 per 1000 | 141 per 1000 </row> <row> 5.6 years – combined HRT | 79–96 per 1000 | 111 per 1000 </row> </datatable2>

  • Explanation:*

Women taking HRT had significantly lower fracture rates than those who did not, across both estrogen-only and combined regimens. - Source: [PubMed – WHI Analysis](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com) 

  RiskModel: RiskofNeverTakingHRT/Data:FractureRiskModel
    Content: 
Fracture_WithoutHRT = Fracture_WithoutHRT  
Fracture_WithHRT = Fracture_WithHRT

Cardiovascular, Stroke, and VTE Risk

<datatable2 name="CardiovascularRiskTable"> <head> Cardio_Label | Cardio_WithHRT | Cardio_WithoutHRT </head> <row> Coronary heart disease | 157 per 10,000 | 132 per 10,000 </row> <row> Stroke | 44 per 10,000 | 32 per 10,000 </row> <row> Venous thromboembolism (VTE) | 34 per 10,000 | 16 per 10,000 </row> </datatable2>

  • Explanation:*

Combined HRT was associated with small increases in cardiovascular events. - Source: [CMAJ Review](https://www.cmaj.ca/content/170/10/1535?utm_source=chatgpt.com) 

  RiskModel: RiskofNeverTakingHRT/Data:CardiovascularRiskModel
    Content: 
Cardio_WithHRT = Cardio_WithHRT[Coronary heart disease]  
Cardio_WithoutHRT = Cardio_WithoutHRT[Coronary heart disease]  


  RiskModel: RiskofNeverTakingHRT/Data:StrokeRiskModel
    Content: 
Cardio_WithHRT = Cardio_WithHRT[Stroke]  
Cardio_WithoutHRT = Cardio_WithoutHRT[Stroke]  


  RiskModel: RiskofNeverTakingHRT/Data:VTERiskModel
    Content: 
Cardio_WithHRT = Cardio_WithHRT[Venous thromboembolism (VTE)]  
Cardio_WithoutHRT = Cardio_WithoutHRT[Venous thromboembolism (VTE)]

Cancer Risk Data

<datatable2 name="CancerRiskTable"> <head> Cancer_Label | Cancer_WithHRT | Cancer_WithoutHRT </head> <row> Breast Cancer (combined HRT) | +9 to +36 per 10,000 | baseline varies </row> <row> Ovarian Cancer | ~1 extra per 1,000 users | baseline varies </row> <row> Endometrial Cancer (combined HRT) | reduced or neutral | baseline varies </row> </datatable2>

  • Explanation:*

Breast and ovarian cancer risks are slightly increased with HRT use. Combined HRT may reduce endometrial cancer risk. - Sources: 

 - [Menopause.org.au](https://www.menopause.org.au/members/ims-menopause-live/use-of-hormone-replacement-therapy-hrt-and-risk-of-breast-cancer?utm_source=chatgpt.com)  
 - [SAGE Review](https://journals.sagepub.com/doi/10.1177/2053369120957514?utm_source=chatgpt.com)

  RiskModel: RiskofNeverTakingHRT/Data:BreastCancerRiskModel
    Content: 
Cancer_WithHRT = Cancer_WithHRT[Breast Cancer (combined HRT)]  


  RiskModel: RiskofNeverTakingHRT/Data:OvarianCancerRiskModel
    Content: 
Cancer_WithHRT = Cancer_WithHRT[Ovarian Cancer]

Dementia Risk (Age ≥65)

<datatable2 name="DementiaRiskTable"> <head> Dementia_Label | Dementia_WithHRT | Dementia_WithoutHRT </head> <row> Women ≥65 using combined HRT | 11 per 1,000 | 9 per 1,000 </row> </datatable2>

  • Explanation:*

HRT started in older age (≥65) may slightly raise the risk of dementia. - Source: [WHI Memory Study – PubMed](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com) 

  RiskModel: RiskofNeverTakingHRT/Data:DementiaRiskModel
    Content: 
Dementia_WithHRT = Dementia_WithHRT  
Dementia_WithoutHRT = Dementia_WithoutHRT

Uncertainty Note

Risk estimates are population-level averages and may vary based on age, timing of HRT, genetics, and other personal health factors.

Generated by an AI assistant.

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