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Risk of Never Taking HRT for Menopause / Data
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= Data for RiskOfNeverTakingHRTForMenopause =
= Data for RiskOfNeverTakingHRTForMenopause =


== Fracture Data ==
== Fracture Risk Data ==
<datatable2 name="FractureRiskTable">
<riskdata table="FractureRiskTable" columns="label|withHRT|withoutHRT">
<head>
<head>
ColumnDuration | ColumnFractureWithHRT | ColumnFractureWithoutHRT
! Scenario (for dropdown)
! Fractures with HRT (per 1000)
! Fractures without HRT (per 1000)
</head>
</head>
<row>
7.1 years – estrogen‑only HRT | 92–113 | 141
7.1 years—oestrogen-only | 92–113 per 1000 | 141 per 1000
5.6 years – combined HRT       | 79–96 | 111
</row>
</riskdata>
<row>
5.6 years—combined HRT | 79–96 per 1000 | 111 per 1000
</row>
</datatable2>


*Explanation:*   
*Explanation:*   
Long-term HRT—either estrogen-only or combined—was associated with lower fracture incidence compared to placebo.   
Women on HRT had fewer fractures than those not taking it—for both estrogen-only and combined regimens.   
- Source: [PubMed](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com)
- Source: [PubMed – WHI WHR Study](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com)


<RiskModel name="FractureRiskModel" calculation="FractureWithoutHRT - FractureWithHRT">
<RiskModel name="FractureRiskModel" calculation="withoutHRT - withHRT">
FractureWithoutHRT = ColumnFractureWithoutHRT 
label = label
FractureWithHRT = ColumnFractureWithHRT 
withHRT = withHRT
withoutHRT = withoutHRT
</RiskModel>
</RiskModel>


== Cardiovascular, Stroke, and VTE Data ==
== Cardiovascular, Stroke, and VTE Risk Data ==
<datatable2 name="CardiovascularRiskTable">
<riskdata table="CardiovascularRiskTable" columns="condition|withHRT|withoutHRT">
<head>
<head>
ColumnCondition | ColumnWithHRT | ColumnWithoutHRT
! Condition (for dropdown)
! Incidence with HRT (per 10,000)
! Incidence without HRT (per 10,000)
</head>
</head>
<row>
Coronary heart disease         | 157 | 132
Coronary heart disease | 157 per 10,000 | 132 per 10,000
Stroke                         | 44 | 32
</row>
Venous thromboembolism (VTE)   | 34 | 16
<row>
</riskdata>
Stroke | 44 per 10,000 | 32 per 10,000
</row>
<row>
Venous thromboembolism (VTE) | 34 per 10,000 | 16 per 10,000
</row>
</datatable2>


*Explanation:*   
*Explanation:*   
Estrogen-progestin therapy slightly increases cardiovascular risks, according to WHI data.   
Combined HRT is associated with slightly higher incidence of CHD, stroke, and VTE.   
- Source: [CMAJ](https://www.cmaj.ca/content/170/10/1535?utm_source=chatgpt.com)
- Source: [CMAJ WHI Summary](https://www.cmaj.ca/content/170/10/1535?utm_source=chatgpt.com)


<RiskModel name="CardiovascularRiskModel" calculation="CHD_WithHRT - CHD_WithoutHRT">
<RiskModel name="CHDRiskModel" calculation="withHRT - withoutHRT">
CHD_WithHRT = ColumnWithHRT[Coronary heart disease] 
condition = 'Coronary heart disease'
CHD_WithoutHRT = ColumnWithoutHRT[Coronary heart disease] 
withHRT = withHRT
withoutHRT = withoutHRT
</RiskModel>
</RiskModel>


<RiskModel name="StrokeRiskModel" calculation="Stroke_WithHRT - Stroke_WithoutHRT">
<RiskModel name="StrokeRiskModel" calculation="withHRT - withoutHRT">
Stroke_WithHRT = ColumnWithHRT[Stroke] 
condition = 'Stroke'
Stroke_WithoutHRT = ColumnWithoutHRT[Stroke] 
withHRT = withHRT
withoutHRT = withoutHRT
</RiskModel>
</RiskModel>


<RiskModel name="VTERiskModel" calculation="VTE_WithHRT - VTE_WithoutHRT">
<RiskModel name="VTERiskModel" calculation="withHRT - withoutHRT">
VTE_WithHRT = ColumnWithHRT[Venous thromboembolism (VTE)] 
condition = 'Venous thromboembolism (VTE)'
VTE_WithoutHRT = ColumnWithoutHRT[Venous thromboembolism (VTE)] 
withHRT = withHRT
withoutHRT = withoutHRT
</RiskModel>
</RiskModel>


== Cancer Risk Data ==
== Cancer Risk Data ==
<datatable2 name="CancerRiskTable">
<riskdata table="CancerRiskTable" columns="cancerType|withHRT|withoutHRT">
<head>
<head>
ColumnCancerType | ColumnWithHRT | ColumnWithoutHRT
! Cancer Type (for dropdown)
! Incidence with HRT (per women-years)
! Baseline without HRT
</head>
</head>
<row>
Breast Cancer (combined HRT) | +9 to +36 per 10,000 | baseline varies
Breast Cancer (combined E+P) | +9 to +36 per 10,000 women-years | Baseline varies
Ovarian Cancer               | ~1 per 1,000         | baseline varies
</row>
Endometrial Cancer (combined HRT) | reduced/neutral | baseline varies
<row>
</riskdata>
Ovarian Cancer | ~1 extra per 1,000 users | Baseline varies
</row>
<row>
Endometrial Cancer | Neutral or ↓ with combined HRT | Baseline varies
</row>
</datatable2>


*Explanation:*   
*Explanation:*   
HRT, particularly combined estrogen-progestin, is associated with increased risk of certain cancers.   
Combined HRT may increase breast and ovarian cancer risk, but appears neutral or protective for endometrial cancer.   
- Sources:   
- Sources:   
   - [Menopause.org.au](https://www.menopause.org.au/members/ims-menopause-live/use-of-hormone-replacement-therapy-hrt-and-risk-of-breast-cancer?utm_source=chatgpt.com)   
   - [Menopause.org.au Breast Cancer](https://www.menopause.org.au/members/ims-menopause-live/use-of-hormone-replacement-therapy-hrt-and-risk-of-breast-cancer?utm_source=chatgpt.com)   
   - [SAGE Journals](https://journals.sagepub.com/doi/10.1177/2053369120957514?utm_source=chatgpt.com)
   - [SAGE Journal Analysis](https://journals.sagepub.com/doi/10.1177/2053369120957514?utm_source=chatgpt.com)


<RiskModel name="BreastCancerRiskModel" calculation="BaselineRisk + BreastCancer_WithHRT_Extra">
<RiskModel name="BreastCancerRiskModel" calculation="withHRT">
BaselineRisk = placeholder 
cancerType = 'Breast Cancer (combined HRT)'
BreastCancer_WithHRT_Extra = ColumnWithHRT[Breast Cancer (combined E+P)] 
withHRT = withHRT
</RiskModel>
</RiskModel>


<RiskModel name="OvarianCancerRiskModel" calculation="BaselineRisk + OvarianCancer_WithHRT_Extra">
<RiskModel name="OvarianCancerRiskModel" calculation="withHRT">
BaselineRisk = placeholder 
cancerType = 'Ovarian Cancer'
OvarianCancer_WithHRT_Extra = ColumnWithHRT[Ovarian Cancer] 
withHRT = withHRT
</RiskModel>
</RiskModel>


== Dementia Data ==
== Dementia Risk Data ==
<datatable2 name="DementiaRiskTable">
<riskdata table="DementiaRiskTable" columns="scenario|withHRT|withoutHRT">
<head>
<head>
ColumnOutcome | ColumnWithHRT | ColumnWithoutHRT
! Scenario (for dropdown)
! Dementia incidence with HRT (per 1000)
! Dementia incidence without HRT (per 1000)
</head>
</head>
<row>
Women ≥65, combined HRT | 11 | 9
Dementia in women ≥65 yrs (combined HRT) | 11 per 1000 | 9 per 1000
</riskdata>
</row>
</datatable2>


*Explanation:*   
*Explanation:*   
In women aged 65 and older, dementia risk was slightly higher in those on HRT.   
In women aged 65+, combined HRT is tied to slightly higher dementia risk.   
- Source: [PubMed](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com)
- Source: [WHI Memory Study – PubMed](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com)


<RiskModel name="DementiaRiskModel" calculation="Dementia_WithHRT - Dementia_WithoutHRT">
<RiskModel name="DementiaRiskModel" calculation="withHRT - withoutHRT">
Dementia_WithHRT = ColumnWithHRT[Dementia in women ≥65 yrs (combined HRT)] 
scenario = 'Women ≥65, combined HRT'
Dementia_WithoutHRT = ColumnWithoutHRT[Dementia in women ≥65 yrs (combined HRT)] 
withHRT = withHRT
withoutHRT = withoutHRT
</RiskModel>
</RiskModel>


== Uncertainty Note ==
== Uncertainty Note ==
Risks are based on population averages and may vary significantly by age, health status, geography, and timing of HRT initiation.
These figures represent population averages and may not apply to every individual due to variables like geography, age at menopause, HRT type, and personal health.


Generated by an AI assistant.
Generated by an AI assistant.

Latest revision as of 17:34, 12 September 2025

Data for RiskOfNeverTakingHRTForMenopause

Fracture Risk Data

Scenario (for dropdown) Fractures with HRT (per 1000) Fractures without HRT (per 1000)

7.1 years – estrogen‑only HRT 

92–113 

141

5.6 years – combined HRT 

79–96  

111
  • Explanation:*

Women on HRT had fewer fractures than those not taking it—for both estrogen-only and combined regimens. - Source: [PubMed – WHI WHR Study](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com) 

  RiskModel: RiskofNeverTakingHRT/Data:FractureRiskModel
    Content: 
label = label
withHRT = withHRT
withoutHRT = withoutHRT

Cardiovascular, Stroke, and VTE Risk Data

Condition (for dropdown) Incidence with HRT (per 10,000) Incidence without HRT (per 10,000)

Coronary heart disease 

157 

132

Stroke 

44  

32

Venous thromboembolism (VTE) 

34  

16
  • Explanation:*

Combined HRT is associated with slightly higher incidence of CHD, stroke, and VTE. - Source: [CMAJ WHI Summary](https://www.cmaj.ca/content/170/10/1535?utm_source=chatgpt.com) 

  RiskModel: RiskofNeverTakingHRT/Data:CHDRiskModel
    Content: 
condition = 'Coronary heart disease'
withHRT = withHRT
withoutHRT = withoutHRT


  RiskModel: RiskofNeverTakingHRT/Data:StrokeRiskModel
    Content: 
condition = 'Stroke'
withHRT = withHRT
withoutHRT = withoutHRT


  RiskModel: RiskofNeverTakingHRT/Data:VTERiskModel
    Content: 
condition = 'Venous thromboembolism (VTE)'
withHRT = withHRT
withoutHRT = withoutHRT

Cancer Risk Data

Cancer Type (for dropdown) Incidence with HRT (per women-years) Baseline without HRT

Breast Cancer (combined HRT) 

+9 to +36 per 10,000 

baseline varies

Ovarian Cancer 

~1 per 1,000         

baseline varies

Endometrial Cancer (combined HRT) 

reduced/neutral 

baseline varies
  • Explanation:*

Combined HRT may increase breast and ovarian cancer risk, but appears neutral or protective for endometrial cancer. - Sources: 

 - [Menopause.org.au Breast Cancer](https://www.menopause.org.au/members/ims-menopause-live/use-of-hormone-replacement-therapy-hrt-and-risk-of-breast-cancer?utm_source=chatgpt.com)  
 - [SAGE Journal Analysis](https://journals.sagepub.com/doi/10.1177/2053369120957514?utm_source=chatgpt.com)

  RiskModel: RiskofNeverTakingHRT/Data:BreastCancerRiskModel
    Content: 
cancerType = 'Breast Cancer (combined HRT)'
withHRT = withHRT


  RiskModel: RiskofNeverTakingHRT/Data:OvarianCancerRiskModel
    Content: 
cancerType = 'Ovarian Cancer'
withHRT = withHRT

Dementia Risk Data

Scenario (for dropdown) Dementia incidence with HRT (per 1000) Dementia incidence without HRT (per 1000)

Women ≥65, combined HRT 

11 

9
  • Explanation:*

In women aged 65+, combined HRT is tied to slightly higher dementia risk. - Source: [WHI Memory Study – PubMed](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com) 

  RiskModel: RiskofNeverTakingHRT/Data:DementiaRiskModel
    Content: 
scenario = 'Women ≥65, combined HRT'
withHRT = withHRT
withoutHRT = withoutHRT

Uncertainty Note

These figures represent population averages and may not apply to every individual due to variables like geography, age at menopause, HRT type, and personal health.

Generated by an AI assistant.

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