Latest revision as of 00:16, 8 September 2025

Risk of Never Taking Hormone Replacement Therapy (HRT) During Menopause

Hormone Replacement Therapy (HRT), also known as Menopausal Hormone Therapy (MHT), is used to manage menopausal symptoms and reduce long-term risks such as osteoporosis. This page estimates the potential risks of **not using HRT**, including fracture, cardiovascular disease, cancer, and dementia outcomes.

Your Inputs

Please answer the following questions to generate a personalized estimate.

How many years have you gone without HRT? This affects the degree of bone loss and fracture risk. [{"label":"7.1\u202fyears\u202f\u2013\u202festrogen\u2011only HRT ","withHRT":" 92\u2013113 ","withoutHRT":" 141"},{"label":"5.6\u202fyears\u202f\u2013\u202fcombined HRT ","withHRT":" 79\u201396 ","withoutHRT":" 111"}]

What are the cardiovascular and clotting risks without HRT? Includes CHD, stroke, and venous thromboembolism (VTE). [{"condition":"Coronary heart disease ","withHRT":" 157 ","withoutHRT":" 132"},{"condition":"Stroke ","withHRT":" 44 ","withoutHRT":" 32"},{"condition":"Venous thromboembolism (VTE) ","withHRT":" 34 ","withoutHRT":" 16"}]

What is your cancer-related risk profile? Includes breast, ovarian, and endometrial cancer outcomes. [{"cancerType":"Breast Cancer (combined HRT) ","withHRT":" +9 to +36 per 10,000 ","withoutHRT":" baseline varies"},{"cancerType":"Ovarian Cancer ","withHRT":" ~1 per 1,000 ","withoutHRT":" baseline varies"},{"cancerType":"Endometrial Cancer (combined HRT) ","withHRT":" reduced\/neutral ","withoutHRT":" baseline varies"}]

Are you 65 or older and concerned about dementia risk? Data suggests a small increased dementia risk when HRT is started after age 65. [{"scenario":"Women \u226565, combined HRT ","withHRT":" 11 ","withoutHRT":" 9"}]

Your Results

Fracture Risk Reduction from HRT:

Cardiovascular Risk Increases with HRT: riskdisplay: can't find riskmodel named CardiovascularRiskModel

Cancer Risk Increases with HRT:

Dementia Risk Increase with HRT (Age ≥65):

See the data page for full tables, sources, and model formulas.

Generated by an AI assistant.

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-# Risk of Never Taking Hormone Replacement Therapy (HRT)
-This page provides a risk calculator for health outcomes associated with not taking hormone replacement therapy (HRT) during menopause. It focuses on risks for postmenopausal women, considering factors like age, menopausal status, and exposure duration, based on data from peer-reviewed studies and authoritative sources. Use the inputs below to estimate risks for conditions such as osteoporosis, cardiovascular disease, and menopausal symptoms.
+= Risk of Never Taking Hormone Replacement Therapy (HRT) During Menopause =
-**Note**: This calculator relies on data tables located on the [[RiskofNeverTakingHRT/Data|data subpage]]. Ensure the data subpage is correctly set up in the RiskiPedia environment for the dropdowns to function.
+Hormone Replacement Therapy (HRT), also known as Menopausal Hormone Therapy (MHT), is used to manage menopausal symptoms and reduce long-term risks such as osteoporosis. This page estimates the potential risks of **not using HRT**, including fracture, cardiovascular disease, cancer, and dementia outcomes.
-## Your Inputs
+== Your Inputs ==
-### Age
+Please answer the following questions to generate a personalized estimate.
-Your age affects the likelihood of health outcomes related to not taking HRT. Select your age group from the dropdown below.
-<DropDown table="AgeRiskFactors" column="AgeRange"/>
+'''How many years have you gone without HRT?'''
+This affects the degree of bone loss and fracture risk.
+<DropDown name="FractureDuration" table="FractureRiskTable" />
-### Menopausal Status
+'''What are the cardiovascular and clotting risks without HRT?'''
-Menopausal status influences the severity of symptoms and chronic condition risks. Choose whether you are premenopausal, perimenopausal, or postmenopausal.
+Includes CHD, stroke, and venous thromboembolism (VTE).
+<DropDown name="CardioCondition" table="CardiovascularRiskTable" />
-<DropDown table="MenopausalStatusFactors" column="Status"/>
+'''What is your cancer-related risk profile?'''
+Includes breast, ovarian, and endometrial cancer outcomes.
+<DropDown name="CancerType" table="CancerRiskTable" />
-### Exposure Duration
+'''Are you 65 or older and concerned about dementia risk?'''
-The duration of not taking HRT impacts cumulative risk. Select the time period for which you want to calculate the risk.
+Data suggests a small increased dementia risk when HRT is started after age 65.
+<DropDown name="DementiaScenario" table="DementiaRiskTable" />
-<DropDown table="ExposureDuration" column="Duration"/>
+== Your Results ==
-## Your Results
+'''Fracture Risk Reduction from HRT:'''
+<RiskDisplay model="FractureRiskModel" />
-### Risk of Osteoporotic Fracture
+'''Cardiovascular Risk Increases with HRT:'''
-This shows the estimated risk of experiencing an osteoporotic fracture due to not taking HRT, compared to those who do.
+<RiskDisplay model="CardiovascularRiskModel" />
+<RiskDisplay model="StrokeRiskModel" />
+<RiskDisplay model="VTERiskModel" />
-<RiskDisplay model="FractureRiskModel"/>
+'''Cancer Risk Increases with HRT:'''
+<RiskDisplay model="BreastCancerRiskModel" />
+<RiskDisplay model="OvarianCancerRiskModel" />
-### Risk of Vasomotor Symptoms
+'''Dementia Risk Increase with HRT (Age ≥65):'''
-This estimates the likelihood of experiencing severe vasomotor symptoms (e.g., hot flashes, night sweats) without HRT.
+<RiskDisplay model="DementiaRiskModel" />
-<RiskDisplay model="VasomotorSymptomRiskModel"/>
+See the [[RiskOfNeverTakingHRTForMenopause/Data|data page]] for full tables, sources, and model formulas.
-### Risk of Cardiovascular Disease
+Generated by an AI assistant.
-This calculates the risk of cardiovascular disease, such as heart disease or stroke, associated with not taking HRT.
-<RiskDisplay model="CardiovascularRiskModel"/>
-See the [[RiskofNeverTakingHRT/Data|data page]] for all of the details on how these risks are calculated.
-Generated by Grok, created by xAI