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Risk of Never Taking HRT For Menopause / Data
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RiskOfNeverTakingHRTForMenopause/Data
= Data for RiskOfNeverTakingHRTForMenopause =
1. Bone Fracture Risk
<datatable2 name="FractureRiskTable"> <head> ColumnAgeGroup | ColumnFractureWithHRT | ColumnFractureWithoutHRT </head> <row> “7.1 years—oestrogen-only: 92–113 per 1000; placebo: 141 per 1000” </row> <row> “5.6 years—combined HT: 79–96 per 1000; placebo: 111 per 1000” </row> </datatable2>


Explanation:
== Fracture Risk Data ==
This table shows observed clinical fracture incidence in women using HRT versus those not using it, from trial data. Studies show that estrogen-only HRT reduced fractures from ~141 to between 92–113 per 1,000, and combined HRT reduced from ~111 to between 79–96 per 1,000.
<riskdata table="FractureRiskTable" columns="label|withHRT|withoutHRT">
<head>
! Scenario (for dropdown)
! Fractures with HRT (per 1000)
! Fractures without HRT (per 1000)
</head>
7.1 years – estrogen‑only HRT | 92–113 | 141
5.6 years – combined HRT       | 79–96  | 111
</riskdata>


Source:  
*Explanation:* 
PubMed
Women on HRT had fewer fractures than those not taking it—for both estrogen-only and combined regimens. 
- Source: [PubMed – WHI WHR Study](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com)


< RiskModel FractureReductionModel>
<RiskModel name="FractureRiskModel" calculation="withoutHRT - withHRT">
RiskWithoutHRT = ColumnFractureWithoutHRT
label = label
RiskWithHRT = ColumnFractureWithHRT
withHRT = withHRT
RiskDifference = RiskWithoutHRT – RiskWithHRT
withoutHRT = withoutHRT
</RiskModel>
</RiskModel>


2. Cardiovascular, Stroke, and Thrombosis Risks
== Cardiovascular, Stroke, and VTE Risk Data ==
<datatable2 name="CardiovascularRiskTable"> <head> ColumnCondition | ColumnWithHRT | ColumnWithoutHRT </head> <row> “Coronary heart disease: 37 vs 30 per 10,000 per year” </row> <row> “Stroke: 29 vs 21 per 10,000 per year” </row> <row> “Blood clots (total VTE): 34 vs 16 per 10,000 per year” </row> </datatable2>
<riskdata table="CardiovascularRiskTable" columns="condition|withHRT|withoutHRT">
<head>
! Condition (for dropdown)
! Incidence with HRT (per 10,000)
! Incidence without HRT (per 10,000)
</head>
Coronary heart disease        | 157 | 132
Stroke                          | 44  | 32
Venous thromboembolism (VTE)   | 34 | 16
</riskdata>


Explanation:
*Explanation:* 
Combined HRT was associated with slightly higher incidence of coronary heart disease, stroke, and venous thromboembolism compared to those without HRT (per 10,000 women per year).
Combined HRT is associated with slightly higher incidence of CHD, stroke, and VTE. 
- Source: [CMAJ WHI Summary](https://www.cmaj.ca/content/170/10/1535?utm_source=chatgpt.com)


Source:
<RiskModel name="CHDRiskModel" calculation="withHRT - withoutHRT">
Government of Canada
condition = 'Coronary heart disease'
withHRT = withHRT
withoutHRT = withoutHRT
</RiskModel>


< RiskModel CardiovascularModel>
<RiskModel name="StrokeRiskModel" calculation="withHRT - withoutHRT">
RiskWithoutHRT_CHD = ColumnWithoutHRT (CHD)
condition = 'Stroke'
RiskWithHRT_CHD = ColumnWithHRT (CHD)
withHRT = withHRT
... similarly for stroke and VTE.
withoutHRT = withoutHRT
</RiskModel>
</RiskModel>


3. Cancer Risks
<RiskModel name="VTERiskModel" calculation="withHRT - withoutHRT">
<datatable2 name="CancerRiskTable"> <head> ColumnCancerType | ColumnWithHRT | ColumnWithoutHRT </head> <row> “Breast cancer (combined E+P): 9‑36 extra cases per 10,000 women‑years” </row> <row> “Ovarian cancer: ~1 extra per 1000 users (≈1 per 5000 women‑years)” </row> <row> “Endometrial cancer: neutral or possible reduction with combined HRT” </row> </datatable2>
condition = 'Venous thromboembolism (VTE)'
withHRT = withHRT
withoutHRT = withoutHRT
</RiskModel>


Explanation:
== Cancer Risk Data ==
Long-term combined HRT may produce between 9 to 36 additional breast cancer cases per 10,000 women-years. Ovarian cancer risk is modestly elevated (~1 extra per 1,000 users, equating to 1 per 5,000 per year), while combined HRT may not increase—and may lower—endometrial cancer risk.
<riskdata table="CancerRiskTable" columns="cancerType|withHRT|withoutHRT">
<head>
! Cancer Type (for dropdown)
! Incidence with HRT (per women-years)
! Baseline without HRT
</head>
Breast Cancer (combined HRT) | +9 to +36 per 10,000 | baseline varies
Ovarian Cancer              | ~1 per 1,000         | baseline varies
Endometrial Cancer (combined HRT) | reduced/neutral | baseline varies
</riskdata>


Sources:  
*Explanation:* 
menopause.org.au
Combined HRT may increase breast and ovarian cancer risk, but appears neutral or protective for endometrial cancer. 
SAGE Journals
- Sources:
Government of Canada
  - [Menopause.org.au Breast Cancer](https://www.menopause.org.au/members/ims-menopause-live/use-of-hormone-replacement-therapy-hrt-and-risk-of-breast-cancer?utm_source=chatgpt.com) 
  - [SAGE Journal Analysis](https://journals.sagepub.com/doi/10.1177/2053369120957514?utm_source=chatgpt.com)


< RiskModel CancerModel>
<RiskModel name="BreastCancerRiskModel" calculation="withHRT">
BreastRiskWithoutHRT = baseline (not in table)
cancerType = 'Breast Cancer (combined HRT)'
BreastRiskWithHRT = BreastRiskWithoutHRT + ColumnWithHRT (breast)
withHRT = withHRT
… similarly for ovarian, endometrial.
</RiskModel>
</RiskModel>


4. All‑Cause Mortality & Dementia (older women)
<RiskModel name="OvarianCancerRiskModel" calculation="withHRT">
<datatable2 name="MortalityDementiaRiskTable"> <head> ColumnOutcome | ColumnWithHRT | ColumnWithoutHRT </head> <row> “Dementia (≥65 yrs, combined HRT): 45 vs 22 per 10,000 per year” </row> </datatable2>
cancerType = 'Ovarian Cancer'
withHRT = withHRT
</RiskModel>


Explanation:
== Dementia Risk Data ==
In women aged 65 or older, combined HRT was associated with an additional ~23 dementia cases per 10,000 women per year compared to non-use.
<riskdata table="DementiaRiskTable" columns="scenario|withHRT|withoutHRT">
<head>
! Scenario (for dropdown)
! Dementia incidence with HRT (per 1000)
! Dementia incidence without HRT (per 1000)
</head>
Women ≥65, combined HRT | 11 | 9
</riskdata>


Source:  
*Explanation:* 
Government of Canada
In women aged 65+, combined HRT is tied to slightly higher dementia risk. 
- Source: [WHI Memory Study – PubMed](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com)


< RiskModel DementiaModel>
<RiskModel name="DementiaRiskModel" calculation="withHRT - withoutHRT">
RiskWithoutHRT = ColumnWithoutHRT
scenario = 'Women ≥65, combined HRT'
RiskWithHRT = ColumnWithHRT
withHRT = withHRT
Difference = RiskWithHRT – RiskWithoutHRT
withoutHRT = withoutHRT
</RiskModel>
</RiskModel>


Uncertainty Note
== Uncertainty Note ==
 
These figures represent population averages and may not apply to every individual due to variables like geography, age at menopause, HRT type, and personal health.
Risks and risk reductions are based on averages across populations. Individual outcomes can vary greatly according to personal health status, timing relative to menopause onset, formulation and dosage of HRT, and geographic or demographic factors.


Generated by an AI assistant.
Generated by an AI assistant.

Latest revision as of 17:34, 12 September 2025

Data for RiskOfNeverTakingHRTForMenopause

Fracture Risk Data

Scenario (for dropdown) Fractures with HRT (per 1000) Fractures without HRT (per 1000)

7.1 years – estrogen‑only HRT 

92–113 

141

5.6 years – combined HRT 

79–96  

111
  • Explanation:*

Women on HRT had fewer fractures than those not taking it—for both estrogen-only and combined regimens. - Source: [PubMed – WHI WHR Study](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com) 

  RiskModel: RiskofNeverTakingHRT/Data:FractureRiskModel
    Content: 
label = label
withHRT = withHRT
withoutHRT = withoutHRT

Cardiovascular, Stroke, and VTE Risk Data

Condition (for dropdown) Incidence with HRT (per 10,000) Incidence without HRT (per 10,000)

Coronary heart disease 

157 

132

Stroke 

44  

32

Venous thromboembolism (VTE) 

34  

16
  • Explanation:*

Combined HRT is associated with slightly higher incidence of CHD, stroke, and VTE. - Source: [CMAJ WHI Summary](https://www.cmaj.ca/content/170/10/1535?utm_source=chatgpt.com) 

  RiskModel: RiskofNeverTakingHRT/Data:CHDRiskModel
    Content: 
condition = 'Coronary heart disease'
withHRT = withHRT
withoutHRT = withoutHRT


  RiskModel: RiskofNeverTakingHRT/Data:StrokeRiskModel
    Content: 
condition = 'Stroke'
withHRT = withHRT
withoutHRT = withoutHRT


  RiskModel: RiskofNeverTakingHRT/Data:VTERiskModel
    Content: 
condition = 'Venous thromboembolism (VTE)'
withHRT = withHRT
withoutHRT = withoutHRT

Cancer Risk Data

Cancer Type (for dropdown) Incidence with HRT (per women-years) Baseline without HRT

Breast Cancer (combined HRT) 

+9 to +36 per 10,000 

baseline varies

Ovarian Cancer 

~1 per 1,000         

baseline varies

Endometrial Cancer (combined HRT) 

reduced/neutral 

baseline varies
  • Explanation:*

Combined HRT may increase breast and ovarian cancer risk, but appears neutral or protective for endometrial cancer. - Sources: 

 - [Menopause.org.au Breast Cancer](https://www.menopause.org.au/members/ims-menopause-live/use-of-hormone-replacement-therapy-hrt-and-risk-of-breast-cancer?utm_source=chatgpt.com)  
 - [SAGE Journal Analysis](https://journals.sagepub.com/doi/10.1177/2053369120957514?utm_source=chatgpt.com)

  RiskModel: RiskofNeverTakingHRT/Data:BreastCancerRiskModel
    Content: 
cancerType = 'Breast Cancer (combined HRT)'
withHRT = withHRT


  RiskModel: RiskofNeverTakingHRT/Data:OvarianCancerRiskModel
    Content: 
cancerType = 'Ovarian Cancer'
withHRT = withHRT

Dementia Risk Data

Scenario (for dropdown) Dementia incidence with HRT (per 1000) Dementia incidence without HRT (per 1000)

Women ≥65, combined HRT 

11 

9
  • Explanation:*

In women aged 65+, combined HRT is tied to slightly higher dementia risk. - Source: [WHI Memory Study – PubMed](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com) 

  RiskModel: RiskofNeverTakingHRT/Data:DementiaRiskModel
    Content: 
scenario = 'Women ≥65, combined HRT'
withHRT = withHRT
withoutHRT = withoutHRT

Uncertainty Note

These figures represent population averages and may not apply to every individual due to variables like geography, age at menopause, HRT type, and personal health.

Generated by an AI assistant.

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