Latest revision as of 00:16, 8 September 2025

Risk of Never Taking Hormone Replacement Therapy (HRT) During Menopause

Hormone Replacement Therapy (HRT), also known as Menopausal Hormone Therapy (MHT), is used to manage menopausal symptoms and reduce long-term risks such as osteoporosis. This page estimates the potential risks of **not using HRT**, including fracture, cardiovascular disease, cancer, and dementia outcomes.

Your Inputs

Please answer the following questions to generate a personalized estimate.

How many years have you gone without HRT? This affects the degree of bone loss and fracture risk. [{"label":"7.1\u202fyears\u202f\u2013\u202festrogen\u2011only HRT ","withHRT":" 92\u2013113 ","withoutHRT":" 141"},{"label":"5.6\u202fyears\u202f\u2013\u202fcombined HRT ","withHRT":" 79\u201396 ","withoutHRT":" 111"}]

What are the cardiovascular and clotting risks without HRT? Includes CHD, stroke, and venous thromboembolism (VTE). [{"condition":"Coronary heart disease ","withHRT":" 157 ","withoutHRT":" 132"},{"condition":"Stroke ","withHRT":" 44 ","withoutHRT":" 32"},{"condition":"Venous thromboembolism (VTE) ","withHRT":" 34 ","withoutHRT":" 16"}]

What is your cancer-related risk profile? Includes breast, ovarian, and endometrial cancer outcomes. [{"cancerType":"Breast Cancer (combined HRT) ","withHRT":" +9 to +36 per 10,000 ","withoutHRT":" baseline varies"},{"cancerType":"Ovarian Cancer ","withHRT":" ~1 per 1,000 ","withoutHRT":" baseline varies"},{"cancerType":"Endometrial Cancer (combined HRT) ","withHRT":" reduced\/neutral ","withoutHRT":" baseline varies"}]

Are you 65 or older and concerned about dementia risk? Data suggests a small increased dementia risk when HRT is started after age 65. [{"scenario":"Women \u226565, combined HRT ","withHRT":" 11 ","withoutHRT":" 9"}]

Your Results

Fracture Risk Reduction from HRT:

Cardiovascular Risk Increases with HRT: riskdisplay: can't find riskmodel named CardiovascularRiskModel

Cancer Risk Increases with HRT:

Dementia Risk Increase with HRT (Age ≥65):

See the data page for full tables, sources, and model formulas.

Generated by an AI assistant.

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 = Risk of Never Taking Hormone Replacement Therapy (HRT) During Menopause =
-This calculator estimates the potential risks of not initiating HRT during menopause, including effects on fracture, cardiovascular, cancer, and dementia outcomes.
+Hormone Replacement Therapy (HRT), also known as Menopausal Hormone Therapy (MHT), is used to manage menopausal symptoms and reduce long-term risks such as osteoporosis. This page estimates the potential risks of **not using HRT**, including fracture, cardiovascular disease, cancer, and dementia outcomes.
 == Your Inputs ==
-Below are the key factors that influence risk. Please select an option for each:
-'''Age at Menopause''' (earlier menopause may elevate long-term fracture risk)
+Please answer the following questions to generate a personalized estimate.
-<DropDown name="AgeAtMenopause">
-'''Duration Without HRT''' (time since menopause without hormone therapy)
+'''How many years have you gone without HRT?'''
-<DropDown name="YearsWithoutHRT">
+This affects the degree of bone loss and fracture risk.
+<DropDown name="FractureDuration" table="FractureRiskTable" />
-'''Fracture Risk Without HRT vs With HRT'''
+'''What are the cardiovascular and clotting risks without HRT?'''
-<DropDown name="FractureRisk">
+Includes CHD, stroke, and venous thromboembolism (VTE).
+<DropDown name="CardioCondition" table="CardiovascularRiskTable" />
-'''Cardiovascular, Stroke, and VTE Risk Without HRT vs With HRT'''
+'''What is your cancer-related risk profile?'''
-<DropDown name="CardiovascularRisk">
+Includes breast, ovarian, and endometrial cancer outcomes.
+<DropDown name="CancerType" table="CancerRiskTable" />
-'''Breast Cancer Risk Without HRT vs With HRT'''
+'''Are you 65 or older and concerned about dementia risk?'''
-<DropDown name="CancerRisk">
+Data suggests a small increased dementia risk when HRT is started after age 65.
+<DropDown name="DementiaScenario" table="DementiaRiskTable" />
-'''Dementia Risk (e.g., women over age 65) Without HRT vs With HRT'''
+== Your Results ==
-<DropDown name="DementiaRisk">
-== Your Results ==
+'''Fracture Risk Reduction from HRT:'''
 <RiskDisplay model="FractureRiskModel" />
+'''Cardiovascular Risk Increases with HRT:'''
 <RiskDisplay model="CardiovascularRiskModel" />
+<RiskDisplay model="StrokeRiskModel" />
+<RiskDisplay model="VTERiskModel" />
-<RiskDisplay model="CancerRiskModel" />
+'''Cancer Risk Increases with HRT:'''
+<RiskDisplay model="BreastCancerRiskModel" />
+<RiskDisplay model="OvarianCancerRiskModel" />
+'''Dementia Risk Increase with HRT (Age ≥65):'''
 <RiskDisplay model="DementiaRiskModel" />
-See the [[RiskOfNeverTakingHRTForMenopause/Data|data subpage]] for full tables, sources, and model definitions.
+See the [[RiskOfNeverTakingHRTForMenopause/Data|data page]] for full tables, sources, and model formulas.
 Generated by an AI assistant.