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Risk of Never Taking HRT For Menopause / Data
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= Data for RiskOfNeverTakingHRTForMenopause =
= Data for RiskOfNeverTakingHRTForMenopause =


== Fracture Data ==
== Fracture Risk Data ==
<datatable2 name="FractureRiskTable">
<riskdata table="FractureRiskTable" columns="label|withHRT|withoutHRT">
<head>
<head>
ColumnDuration | ColumnFractureWithHRT | ColumnFractureWithoutHRT
! Scenario (for dropdown)
! Fractures with HRT (per 1000)
! Fractures without HRT (per 1000)
</head>
</head>
<row>
7.1 years – estrogen‑only HRT | 92–113 | 141
7.1 years—oestrogen-only | 92–113 per 1000 | 141 per 1000
5.6 years – combined HRT       | 79–96 | 111
</row>
</riskdata>
<row>
5.6 years—combined HRT | 79–96 per 1000 | 111 per 1000
</row>
</datatable2>


*Explanation:*   
*Explanation:*   
Long-term HRT—either estrogen-only or combined—was associated with lower fracture incidence compared to placebo. Estrogen-only: fracture incidence decreased from 141 to 92–113 per 1000 over ~7.1 years; combined HRT: from 111 to 79–96 per 1000 over ~5.6 years.   
Women on HRT had fewer fractures than those not taking it—for both estrogen-only and combined regimens.   
- Source: [PubMed](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com)
- Source: [PubMed – WHI WHR Study](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com)


<RiskModel name="FractureRiskModel">
<RiskModel name="FractureRiskModel" calculation="withoutHRT - withHRT">
FractureWithoutHRT = ColumnFractureWithoutHRT 
label = label
FractureWithHRT = ColumnFractureWithHRT 
withHRT = withHRT
FractureRiskReduction = FractureWithoutHRT - FractureWithHRT 
withoutHRT = withoutHRT
</RiskModel>
</RiskModel>


== Cardiovascular, Stroke, and VTE Data ==
== Cardiovascular, Stroke, and VTE Risk Data ==
<datatable2 name="CardiovascularRiskTable">
<riskdata table="CardiovascularRiskTable" columns="condition|withHRT|withoutHRT">
<head>
<head>
ColumnCondition | ColumnWithHRT | ColumnWithoutHRT
! Condition (for dropdown)
! Incidence with HRT (per 10,000)
! Incidence without HRT (per 10,000)
</head>
</head>
<row>
Coronary heart disease         | 157 | 132
Coronary heart disease | 157 per 10,000 | 132 per 10,000
Stroke                         | 44 | 32
</row>
Venous thromboembolism (VTE)   | 34 | 16
<row>
</riskdata>
Stroke | 44 per 10,000 | 32 per 10,000
</row>
<row>
Venous thromboembolism (VTE) | 34 per 10,000 | 16 per 10,000
</row>
</datatable2>


*Explanation:*   
*Explanation:*   
In WHI data, estrogen-progestin therapy was associated with small increases in cardiovascular events: CHD (25 more per 10,000), stroke (12 more), and VTE (18 more).   
Combined HRT is associated with slightly higher incidence of CHD, stroke, and VTE.   
- Source: [CMAJ](https://www.cmaj.ca/content/170/10/1535?utm_source=chatgpt.com)
- Source: [CMAJ WHI Summary](https://www.cmaj.ca/content/170/10/1535?utm_source=chatgpt.com)


<RiskModel name="CardiovascularRiskModel">
<RiskModel name="CHDRiskModel" calculation="withHRT - withoutHRT">
CHD_WithHRT = ColumnWithHRT[Coronary heart disease]   
condition = 'Coronary heart disease'
CHD_WithoutHRT = ColumnWithoutHRT[Coronary heart disease]
withHRT = withHRT
Stroke_Wi_
withoutHRT = withoutHRT
</RiskModel>
 
<RiskModel name="StrokeRiskModel" calculation="withHRT - withoutHRT">
condition = 'Stroke'
withHRT = withHRT
withoutHRT = withoutHRT
</RiskModel>
 
<RiskModel name="VTERiskModel" calculation="withHRT - withoutHRT">
condition = 'Venous thromboembolism (VTE)'
withHRT = withHRT
withoutHRT = withoutHRT
</RiskModel>
 
== Cancer Risk Data ==
<riskdata table="CancerRiskTable" columns="cancerType|withHRT|withoutHRT">
<head>
! Cancer Type (for dropdown)
! Incidence with HRT (per women-years)
! Baseline without HRT
</head>
Breast Cancer (combined HRT) | +9 to +36 per 10,000 | baseline varies
Ovarian Cancer              | ~1 per 1,000        | baseline varies
Endometrial Cancer (combined HRT) | reduced/neutral | baseline varies
</riskdata>
 
*Explanation:* 
Combined HRT may increase breast and ovarian cancer risk, but appears neutral or protective for endometrial cancer. 
- Sources: 
  - [Menopause.org.au Breast Cancer](https://www.menopause.org.au/members/ims-menopause-live/use-of-hormone-replacement-therapy-hrt-and-risk-of-breast-cancer?utm_source=chatgpt.com)  
  - [SAGE Journal Analysis](https://journals.sagepub.com/doi/10.1177/2053369120957514?utm_source=chatgpt.com)
 
<RiskModel name="BreastCancerRiskModel" calculation="withHRT">
cancerType = 'Breast Cancer (combined HRT)'
withHRT = withHRT
</RiskModel>
 
<RiskModel name="OvarianCancerRiskModel" calculation="withHRT">
cancerType = 'Ovarian Cancer'
withHRT = withHRT
</RiskModel>
 
== Dementia Risk Data ==
<riskdata table="DementiaRiskTable" columns="scenario|withHRT|withoutHRT">
<head>
! Scenario (for dropdown)
! Dementia incidence with HRT (per 1000)
! Dementia incidence without HRT (per 1000)
</head>
Women ≥65, combined HRT | 11 | 9
</riskdata>
 
*Explanation:* 
In women aged 65+, combined HRT is tied to slightly higher dementia risk. 
- Source: [WHI Memory Study – PubMed](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com)
 
<RiskModel name="DementiaRiskModel" calculation="withHRT - withoutHRT">
scenario = 'Women ≥65, combined HRT'
withHRT = withHRT
withoutHRT = withoutHRT
</RiskModel>
 
== Uncertainty Note ==
These figures represent population averages and may not apply to every individual due to variables like geography, age at menopause, HRT type, and personal health.
 
Generated by an AI assistant.

Latest revision as of 17:34, 12 September 2025

Data for RiskOfNeverTakingHRTForMenopause

Fracture Risk Data

Scenario (for dropdown) Fractures with HRT (per 1000) Fractures without HRT (per 1000)

7.1 years – estrogen‑only HRT 

92–113 

141

5.6 years – combined HRT 

79–96  

111
  • Explanation:*

Women on HRT had fewer fractures than those not taking it—for both estrogen-only and combined regimens. - Source: [PubMed – WHI WHR Study](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com) 

  RiskModel: RiskofNeverTakingHRT/Data:FractureRiskModel
    Content: 
label = label
withHRT = withHRT
withoutHRT = withoutHRT

Cardiovascular, Stroke, and VTE Risk Data

Condition (for dropdown) Incidence with HRT (per 10,000) Incidence without HRT (per 10,000)

Coronary heart disease 

157 

132

Stroke 

44  

32

Venous thromboembolism (VTE) 

34  

16
  • Explanation:*

Combined HRT is associated with slightly higher incidence of CHD, stroke, and VTE. - Source: [CMAJ WHI Summary](https://www.cmaj.ca/content/170/10/1535?utm_source=chatgpt.com) 

  RiskModel: RiskofNeverTakingHRT/Data:CHDRiskModel
    Content: 
condition = 'Coronary heart disease'
withHRT = withHRT
withoutHRT = withoutHRT


  RiskModel: RiskofNeverTakingHRT/Data:StrokeRiskModel
    Content: 
condition = 'Stroke'
withHRT = withHRT
withoutHRT = withoutHRT


  RiskModel: RiskofNeverTakingHRT/Data:VTERiskModel
    Content: 
condition = 'Venous thromboembolism (VTE)'
withHRT = withHRT
withoutHRT = withoutHRT

Cancer Risk Data

Cancer Type (for dropdown) Incidence with HRT (per women-years) Baseline without HRT

Breast Cancer (combined HRT) 

+9 to +36 per 10,000 

baseline varies

Ovarian Cancer 

~1 per 1,000         

baseline varies

Endometrial Cancer (combined HRT) 

reduced/neutral 

baseline varies
  • Explanation:*

Combined HRT may increase breast and ovarian cancer risk, but appears neutral or protective for endometrial cancer. - Sources: 

 - [Menopause.org.au Breast Cancer](https://www.menopause.org.au/members/ims-menopause-live/use-of-hormone-replacement-therapy-hrt-and-risk-of-breast-cancer?utm_source=chatgpt.com)  
 - [SAGE Journal Analysis](https://journals.sagepub.com/doi/10.1177/2053369120957514?utm_source=chatgpt.com)

  RiskModel: RiskofNeverTakingHRT/Data:BreastCancerRiskModel
    Content: 
cancerType = 'Breast Cancer (combined HRT)'
withHRT = withHRT


  RiskModel: RiskofNeverTakingHRT/Data:OvarianCancerRiskModel
    Content: 
cancerType = 'Ovarian Cancer'
withHRT = withHRT

Dementia Risk Data

Scenario (for dropdown) Dementia incidence with HRT (per 1000) Dementia incidence without HRT (per 1000)

Women ≥65, combined HRT 

11 

9
  • Explanation:*

In women aged 65+, combined HRT is tied to slightly higher dementia risk. - Source: [WHI Memory Study – PubMed](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com) 

  RiskModel: RiskofNeverTakingHRT/Data:DementiaRiskModel
    Content: 
scenario = 'Women ≥65, combined HRT'
withHRT = withHRT
withoutHRT = withoutHRT

Uncertainty Note

These figures represent population averages and may not apply to every individual due to variables like geography, age at menopause, HRT type, and personal health.

Generated by an AI assistant.

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