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Risk of Never Taking HRT For Menopause / Data
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Risk of Never Taking HRT for Menopause / Data
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*Explanation:*   
*Explanation:*   
Long-term HRT—either estrogen-only or combined—was associated with lower fracture incidence compared to placebo. Estrogen-only: fracture incidence decreased from 141 to 92–113 per 1000 over ~7.1 years; combined HRT: from 111 to 79–96 per 1000 over ~5.6 years.   
Long-term HRT—either estrogen-only or combined—was associated with lower fracture incidence compared to placebo.   
- Source: [PubMed](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com)
- Source: [PubMed](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com)


<RiskModel name="FractureRiskModel">
<RiskModel name="FractureRiskModel" calculation="FractureWithoutHRT - FractureWithHRT">
FractureWithoutHRT = ColumnFractureWithoutHRT   
FractureWithoutHRT = ColumnFractureWithoutHRT   
FractureWithHRT = ColumnFractureWithHRT   
FractureWithHRT = ColumnFractureWithHRT   
FractureRiskReduction = FractureWithoutHRT - FractureWithHRT 
</RiskModel>
</RiskModel>


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*Explanation:*   
*Explanation:*   
In WHI data, estrogen-progestin therapy was associated with small increases in cardiovascular events: CHD (25 more per 10,000), stroke (12 more), and VTE (18 more).   
Estrogen-progestin therapy slightly increases cardiovascular risks, according to WHI data.   
- Source: [CMAJ](https://www.cmaj.ca/content/170/10/1535?utm_source=chatgpt.com)
- Source: [CMAJ](https://www.cmaj.ca/content/170/10/1535?utm_source=chatgpt.com)


<RiskModel name="CardiovascularRiskModel">
<RiskModel name="CardiovascularRiskModel" calculation="CHD_WithHRT - CHD_WithoutHRT">
CHD_WithHRT = ColumnWithHRT[Coronary heart disease]   
CHD_WithHRT = ColumnWithHRT[Coronary heart disease]   
CHD_WithoutHRT = ColumnWithoutHRT[Coronary heart disease]   
CHD_WithoutHRT = ColumnWithoutHRT[Coronary heart disease]   
Stroke_Wi_
</RiskModel>
 
<RiskModel name="StrokeRiskModel" calculation="Stroke_WithHRT - Stroke_WithoutHRT">
Stroke_WithHRT = ColumnWithHRT[Stroke] 
Stroke_WithoutHRT = ColumnWithoutHRT[Stroke] 
</RiskModel>
 
<RiskModel name="VTERiskModel" calculation="VTE_WithHRT - VTE_WithoutHRT">
VTE_WithHRT = ColumnWithHRT[Venous thromboembolism (VTE)] 
VTE_WithoutHRT = ColumnWithoutHRT[Venous thromboembolism (VTE)] 
</RiskModel>
 
== Cancer Risk Data ==
<datatable2 name="CancerRiskTable">
<head>
ColumnCancerType | ColumnWithHRT | ColumnWithoutHRT
</head>
<row>
Breast Cancer (combined E+P) | +9 to +36 per 10,000 women-years | Baseline varies
</row>
<row>
Ovarian Cancer | ~1 extra per 1,000 users | Baseline varies
</row>
<row>
Endometrial Cancer | Neutral or ↓ with combined HRT | Baseline varies
</row>
</datatable2>
 
*Explanation:* 
HRT, particularly combined estrogen-progestin, is associated with increased risk of certain cancers. 
- Sources: 
  - [Menopause.org.au](https://www.menopause.org.au/members/ims-menopause-live/use-of-hormone-replacement-therapy-hrt-and-risk-of-breast-cancer?utm_source=chatgpt.com) 
  - [SAGE Journals](https://journals.sagepub.com/doi/10.1177/2053369120957514?utm_source=chatgpt.com)
 
<RiskModel name="BreastCancerRiskModel" calculation="BaselineRisk + BreastCancer_WithHRT_Extra">
BaselineRisk = placeholder 
BreastCancer_WithHRT_Extra = ColumnWithHRT[Breast Cancer (combined E+P)] 
</RiskModel>
 
<RiskModel name="OvarianCancerRiskModel" calculation="BaselineRisk + OvarianCancer_WithHRT_Extra">
BaselineRisk = placeholder 
OvarianCancer_WithHRT_Extra = ColumnWithHRT[Ovarian Cancer] 
</RiskModel>
 
== Dementia Data ==
<datatable2 name="DementiaRiskTable">
<head>
ColumnOutcome | ColumnWithHRT | ColumnWithoutHRT
</head>
<row>
Dementia in women ≥65 yrs (combined HRT) | 11 per 1000 | 9 per 1000
</row>
</datatable2>
 
*Explanation:* 
In women aged 65 and older, dementia risk was slightly higher in those on HRT. 
- Source: [PubMed](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com)
 
<RiskModel name="DementiaRiskModel" calculation="Dementia_WithHRT - Dementia_WithoutHRT">
Dementia_WithHRT = ColumnWithHRT[Dementia in women ≥65 yrs (combined HRT)] 
Dementia_WithoutHRT = ColumnWithoutHRT[Dementia in women ≥65 yrs (combined HRT)] 
</RiskModel>
 
== Uncertainty Note ==
Risks are based on population averages and may vary significantly by age, health status, geography, and timing of HRT initiation.
 
Generated by an AI assistant.

Revision as of 00:13, 8 September 2025

Data for RiskOfNeverTakingHRTForMenopause

Fracture Data

<datatable2 name="FractureRiskTable"> <head> ColumnDuration | ColumnFractureWithHRT | ColumnFractureWithoutHRT </head> <row> 7.1 years—oestrogen-only | 92–113 per 1000 | 141 per 1000 </row> <row> 5.6 years—combined HRT | 79–96 per 1000 | 111 per 1000 </row> </datatable2>

  • Explanation:*

Long-term HRT—either estrogen-only or combined—was associated with lower fracture incidence compared to placebo. - Source: [PubMed](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com) 

  RiskModel: RiskofNeverTakingHRT/Data:FractureRiskModel
    Content: 
FractureWithoutHRT = ColumnFractureWithoutHRT  
FractureWithHRT = ColumnFractureWithHRT

Cardiovascular, Stroke, and VTE Data

<datatable2 name="CardiovascularRiskTable"> <head> ColumnCondition | ColumnWithHRT | ColumnWithoutHRT </head> <row> Coronary heart disease | 157 per 10,000 | 132 per 10,000 </row> <row> Stroke | 44 per 10,000 | 32 per 10,000 </row> <row> Venous thromboembolism (VTE) | 34 per 10,000 | 16 per 10,000 </row> </datatable2>

  • Explanation:*

Estrogen-progestin therapy slightly increases cardiovascular risks, according to WHI data. - Source: [CMAJ](https://www.cmaj.ca/content/170/10/1535?utm_source=chatgpt.com) 

  RiskModel: RiskofNeverTakingHRT/Data:CardiovascularRiskModel
    Content: 
CHD_WithHRT = ColumnWithHRT[Coronary heart disease]  
CHD_WithoutHRT = ColumnWithoutHRT[Coronary heart disease]  


  RiskModel: RiskofNeverTakingHRT/Data:StrokeRiskModel
    Content: 
Stroke_WithHRT = ColumnWithHRT[Stroke]  
Stroke_WithoutHRT = ColumnWithoutHRT[Stroke]  


  RiskModel: RiskofNeverTakingHRT/Data:VTERiskModel
    Content: 
VTE_WithHRT = ColumnWithHRT[Venous thromboembolism (VTE)]  
VTE_WithoutHRT = ColumnWithoutHRT[Venous thromboembolism (VTE)]

Cancer Risk Data

<datatable2 name="CancerRiskTable"> <head> ColumnCancerType | ColumnWithHRT | ColumnWithoutHRT </head> <row> Breast Cancer (combined E+P) | +9 to +36 per 10,000 women-years | Baseline varies </row> <row> Ovarian Cancer | ~1 extra per 1,000 users | Baseline varies </row> <row> Endometrial Cancer | Neutral or ↓ with combined HRT | Baseline varies </row> </datatable2>

  • Explanation:*

HRT, particularly combined estrogen-progestin, is associated with increased risk of certain cancers. - Sources: 

 - [Menopause.org.au](https://www.menopause.org.au/members/ims-menopause-live/use-of-hormone-replacement-therapy-hrt-and-risk-of-breast-cancer?utm_source=chatgpt.com)  
 - [SAGE Journals](https://journals.sagepub.com/doi/10.1177/2053369120957514?utm_source=chatgpt.com)

  RiskModel: RiskofNeverTakingHRT/Data:BreastCancerRiskModel
    Content: 
BaselineRisk = placeholder  
BreastCancer_WithHRT_Extra = ColumnWithHRT[Breast Cancer (combined E+P)]  


  RiskModel: RiskofNeverTakingHRT/Data:OvarianCancerRiskModel
    Content: 
BaselineRisk = placeholder  
OvarianCancer_WithHRT_Extra = ColumnWithHRT[Ovarian Cancer]

Dementia Data

<datatable2 name="DementiaRiskTable"> <head> ColumnOutcome | ColumnWithHRT | ColumnWithoutHRT </head> <row> Dementia in women ≥65 yrs (combined HRT) | 11 per 1000 | 9 per 1000 </row> </datatable2>

  • Explanation:*

In women aged 65 and older, dementia risk was slightly higher in those on HRT. - Source: [PubMed](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com) 

  RiskModel: RiskofNeverTakingHRT/Data:DementiaRiskModel
    Content: 
Dementia_WithHRT = ColumnWithHRT[Dementia in women ≥65 yrs (combined HRT)]  
Dementia_WithoutHRT = ColumnWithoutHRT[Dementia in women ≥65 yrs (combined HRT)]

Uncertainty Note

Risks are based on population averages and may vary significantly by age, health status, geography, and timing of HRT initiation.

Generated by an AI assistant.

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