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Risk of Never Taking HRT for Menopause / Data
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Risk of Never Taking HRT for Menopause / Data
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== Fracture Risk Data ==
== Fracture Risk Data ==
<datatable2 name="FractureRiskTable">
<datatable2 table="FractureRiskTable" columns="label|withHRT|withoutHRT">
<head>
<head>
Fracture_Label | Fracture_WithHRT | Fracture_WithoutHRT
! Scenario (for dropdown)
! Fractures with HRT (per 1000)
! Fractures without HRT (per 1000)
</head>
</head>
<row>
7.1 years – estrogen‑only HRT | 92–113 | 141
7.1 years – estrogen-only HRT | 92–113 per 1000 | 141 per 1000
5.6 years – combined HRT       | 79–96 | 111
</row>
<row>
5.6 years – combined HRT | 79–96 per 1000 | 111 per 1000
</row>
</datatable2>
</datatable2>


*Explanation:*   
*Explanation:*   
Women taking HRT had significantly lower fracture rates than those who did not, across both estrogen-only and combined regimens.   
Women on HRT had fewer fractures than those not taking it—for both estrogen-only and combined regimens.   
- Source: [PubMed – WHI Analysis](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com)
- Source: [PubMed – WHI WHR Study](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com)


<RiskModel name="FractureRiskModel" calculation="Fracture_WithoutHRT - Fracture_WithHRT">
<RiskModel name="FractureRiskModel" calculation="withoutHRT - withHRT">
Fracture_WithoutHRT = Fracture_WithoutHRT 
label = label
Fracture_WithHRT = Fracture_WithHRT 
withHRT = withHRT
withoutHRT = withoutHRT
</RiskModel>
</RiskModel>


== Cardiovascular, Stroke, and VTE Risk ==
== Cardiovascular, Stroke, and VTE Risk Data ==
<datatable2 name="CardiovascularRiskTable">
<datatable2 table="CardiovascularRiskTable" columns="condition|withHRT|withoutHRT">
<head>
<head>
Cardio_Label | Cardio_WithHRT | Cardio_WithoutHRT
! Condition (for dropdown)
! Incidence with HRT (per 10,000)
! Incidence without HRT (per 10,000)
</head>
</head>
<row>
Coronary heart disease         | 157 | 132
Coronary heart disease | 157 per 10,000 | 132 per 10,000
Stroke                         | 44 | 32
</row>
Venous thromboembolism (VTE)   | 34 | 16
<row>
Stroke | 44 per 10,000 | 32 per 10,000
</row>
<row>
Venous thromboembolism (VTE) | 34 per 10,000 | 16 per 10,000
</row>
</datatable2>
</datatable2>


*Explanation:*   
*Explanation:*   
Combined HRT was associated with small increases in cardiovascular events.   
Combined HRT is associated with slightly higher incidence of CHD, stroke, and VTE.   
- Source: [CMAJ Review](https://www.cmaj.ca/content/170/10/1535?utm_source=chatgpt.com)
- Source: [CMAJ WHI Summary](https://www.cmaj.ca/content/170/10/1535?utm_source=chatgpt.com)


<RiskModel name="CardiovascularRiskModel" calculation="Cardio_WithHRT - Cardio_WithoutHRT">
<RiskModel name="CHDRiskModel" calculation="withHRT - withoutHRT">
Cardio_WithHRT = Cardio_WithHRT[Coronary heart disease] 
condition = 'Coronary heart disease'
Cardio_WithoutHRT = Cardio_WithoutHRT[Coronary heart disease] 
withHRT = withHRT
withoutHRT = withoutHRT
</RiskModel>
</RiskModel>


<RiskModel name="StrokeRiskModel" calculation="Cardio_WithHRT - Cardio_WithoutHRT">
<RiskModel name="StrokeRiskModel" calculation="withHRT - withoutHRT">
Cardio_WithHRT = Cardio_WithHRT[Stroke] 
condition = 'Stroke'
Cardio_WithoutHRT = Cardio_WithoutHRT[Stroke] 
withHRT = withHRT
withoutHRT = withoutHRT
</RiskModel>
</RiskModel>


<RiskModel name="VTERiskModel" calculation="Cardio_WithHRT - Cardio_WithoutHRT">
<RiskModel name="VTERiskModel" calculation="withHRT - withoutHRT">
Cardio_WithHRT = Cardio_WithHRT[Venous thromboembolism (VTE)] 
condition = 'Venous thromboembolism (VTE)'
Cardio_WithoutHRT = Cardio_WithoutHRT[Venous thromboembolism (VTE)] 
withHRT = withHRT
withoutHRT = withoutHRT
</RiskModel>
</RiskModel>


== Cancer Risk Data ==
== Cancer Risk Data ==
<datatable2 name="CancerRiskTable">
<datatable2 table="CancerRiskTable" columns="cancerType|withHRT|withoutHRT">
<head>
<head>
Cancer_Label | Cancer_WithHRT | Cancer_WithoutHRT
! Cancer Type (for dropdown)
! Incidence with HRT (per women-years)
! Baseline without HRT
</head>
</head>
<row>
Breast Cancer (combined HRT) | +9 to +36 per 10,000 | baseline varies
Breast Cancer (combined HRT) | +9 to +36 per 10,000 | baseline varies
</row>
Ovarian Cancer               | ~1 per 1,000         | baseline varies
<row>
Endometrial Cancer (combined HRT) | reduced/neutral | baseline varies
Ovarian Cancer | ~1 extra per 1,000 users | baseline varies
</row>
<row>
Endometrial Cancer (combined HRT) | reduced or neutral | baseline varies
</row>
</datatable2>
</datatable2>


*Explanation:*   
*Explanation:*   
Breast and ovarian cancer risks are slightly increased with HRT use. Combined HRT may reduce endometrial cancer risk.   
Combined HRT may increase breast and ovarian cancer risk, but appears neutral or protective for endometrial cancer.   
- Sources:   
- Sources:   
   - [Menopause.org.au](https://www.menopause.org.au/members/ims-menopause-live/use-of-hormone-replacement-therapy-hrt-and-risk-of-breast-cancer?utm_source=chatgpt.com)   
   - [Menopause.org.au Breast Cancer](https://www.menopause.org.au/members/ims-menopause-live/use-of-hormone-replacement-therapy-hrt-and-risk-of-breast-cancer?utm_source=chatgpt.com)   
   - [SAGE Review](https://journals.sagepub.com/doi/10.1177/2053369120957514?utm_source=chatgpt.com)
   - [SAGE Journal Analysis](https://journals.sagepub.com/doi/10.1177/2053369120957514?utm_source=chatgpt.com)


<RiskModel name="BreastCancerRiskModel" calculation="Cancer_WithHRT">
<RiskModel name="BreastCancerRiskModel" calculation="withHRT">
Cancer_WithHRT = Cancer_WithHRT[Breast Cancer (combined HRT)] 
cancerType = 'Breast Cancer (combined HRT)'
withHRT = withHRT
</RiskModel>
</RiskModel>


<RiskModel name="OvarianCancerRiskModel" calculation="Cancer_WithHRT">
<RiskModel name="OvarianCancerRiskModel" calculation="withHRT">
Cancer_WithHRT = Cancer_WithHRT[Ovarian Cancer] 
cancerType = 'Ovarian Cancer'
withHRT = withHRT
</RiskModel>
</RiskModel>


== Dementia Risk (Age ≥65) ==
== Dementia Risk Data ==
<datatable2 name="DementiaRiskTable">
<datatable2 table="DementiaRiskTable" columns="scenario|withHRT|withoutHRT">
<head>
<head>
Dementia_Label | Dementia_WithHRT | Dementia_WithoutHRT
! Scenario (for dropdown)
! Dementia incidence with HRT (per 1000)
! Dementia incidence without HRT (per 1000)
</head>
</head>
<row>
Women ≥65, combined HRT | 11 | 9
Women ≥65 using combined HRT | 11 per 1,000 | 9 per 1,000
</row>
</datatable2>
</datatable2>


*Explanation:*   
*Explanation:*   
HRT started in older age (≥65) may slightly raise the risk of dementia.   
In women aged 65+, combined HRT is tied to slightly higher dementia risk.   
- Source: [WHI Memory Study – PubMed](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com)
- Source: [WHI Memory Study – PubMed](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com)


<RiskModel name="DementiaRiskModel" calculation="Dementia_WithHRT - Dementia_WithoutHRT">
<RiskModel name="DementiaRiskModel" calculation="withHRT - withoutHRT">
Dementia_WithHRT = Dementia_WithHRT 
scenario = 'Women ≥65, combined HRT'
Dementia_WithoutHRT = Dementia_WithoutHRT 
withHRT = withHRT
withoutHRT = withoutHRT
</RiskModel>
</RiskModel>


== Uncertainty Note ==
== Uncertainty Note ==
Risk estimates are population-level averages and may vary based on age, timing of HRT, genetics, and other personal health factors.
These figures represent population averages and may not apply to every individual due to variables like geography, age at menopause, HRT type, and personal health.


Generated by an AI assistant.
Generated by an AI assistant.

Revision as of 00:24, 8 September 2025

Data for RiskOfNeverTakingHRTForMenopause

Fracture Risk Data

<datatable2 table="FractureRiskTable" columns="label|withHRT|withoutHRT"> <head> ! Scenario (for dropdown) ! Fractures with HRT (per 1000) ! Fractures without HRT (per 1000) </head> 7.1 years – estrogen‑only HRT | 92–113 | 141 5.6 years – combined HRT | 79–96 | 111 </datatable2>

  • Explanation:*

Women on HRT had fewer fractures than those not taking it—for both estrogen-only and combined regimens. - Source: [PubMed – WHI WHR Study](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com) 

  RiskModel: RiskofNeverTakingHRT/Data:FractureRiskModel
    Content: 
label = label
withHRT = withHRT
withoutHRT = withoutHRT

Cardiovascular, Stroke, and VTE Risk Data

<datatable2 table="CardiovascularRiskTable" columns="condition|withHRT|withoutHRT"> <head> ! Condition (for dropdown) ! Incidence with HRT (per 10,000) ! Incidence without HRT (per 10,000) </head> Coronary heart disease | 157 | 132 Stroke | 44 | 32 Venous thromboembolism (VTE) | 34 | 16 </datatable2>

  • Explanation:*

Combined HRT is associated with slightly higher incidence of CHD, stroke, and VTE. - Source: [CMAJ WHI Summary](https://www.cmaj.ca/content/170/10/1535?utm_source=chatgpt.com) 

  RiskModel: RiskofNeverTakingHRT/Data:CHDRiskModel
    Content: 
condition = 'Coronary heart disease'
withHRT = withHRT
withoutHRT = withoutHRT


  RiskModel: RiskofNeverTakingHRT/Data:StrokeRiskModel
    Content: 
condition = 'Stroke'
withHRT = withHRT
withoutHRT = withoutHRT


  RiskModel: RiskofNeverTakingHRT/Data:VTERiskModel
    Content: 
condition = 'Venous thromboembolism (VTE)'
withHRT = withHRT
withoutHRT = withoutHRT

Cancer Risk Data

<datatable2 table="CancerRiskTable" columns="cancerType|withHRT|withoutHRT"> <head> ! Cancer Type (for dropdown) ! Incidence with HRT (per women-years) ! Baseline without HRT </head> Breast Cancer (combined HRT) | +9 to +36 per 10,000 | baseline varies Ovarian Cancer | ~1 per 1,000 | baseline varies Endometrial Cancer (combined HRT) | reduced/neutral | baseline varies </datatable2>

  • Explanation:*

Combined HRT may increase breast and ovarian cancer risk, but appears neutral or protective for endometrial cancer. - Sources: 

 - [Menopause.org.au Breast Cancer](https://www.menopause.org.au/members/ims-menopause-live/use-of-hormone-replacement-therapy-hrt-and-risk-of-breast-cancer?utm_source=chatgpt.com)  
 - [SAGE Journal Analysis](https://journals.sagepub.com/doi/10.1177/2053369120957514?utm_source=chatgpt.com)

  RiskModel: RiskofNeverTakingHRT/Data:BreastCancerRiskModel
    Content: 
cancerType = 'Breast Cancer (combined HRT)'
withHRT = withHRT


  RiskModel: RiskofNeverTakingHRT/Data:OvarianCancerRiskModel
    Content: 
cancerType = 'Ovarian Cancer'
withHRT = withHRT

Dementia Risk Data

<datatable2 table="DementiaRiskTable" columns="scenario|withHRT|withoutHRT"> <head> ! Scenario (for dropdown) ! Dementia incidence with HRT (per 1000) ! Dementia incidence without HRT (per 1000) </head> Women ≥65, combined HRT | 11 | 9 </datatable2>

  • Explanation:*

In women aged 65+, combined HRT is tied to slightly higher dementia risk. - Source: [WHI Memory Study – PubMed](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com) 

  RiskModel: RiskofNeverTakingHRT/Data:DementiaRiskModel
    Content: 
scenario = 'Women ≥65, combined HRT'
withHRT = withHRT
withoutHRT = withoutHRT

Uncertainty Note

These figures represent population averages and may not apply to every individual due to variables like geography, age at menopause, HRT type, and personal health.

Generated by an AI assistant.

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