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RiskofNeverTakingHRT/Data

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Revision as of 00:19, 8 September 2025 by Rischi (talk | contribs) (Risk of Never Taking HRT for Menopause / Data)

Data for RiskOfNeverTakingHRTForMenopause

Fracture Risk Data

<datatable2 name="FractureRiskTable"> <head> Fracture_Label | Fracture_WithHRT | Fracture_WithoutHRT </head> <row> 7.1 years – estrogen-only HRT | 92–113 per 1000 | 141 per 1000 </row> <row> 5.6 years – combined HRT | 79–96 per 1000 | 111 per 1000 </row> </datatable2>

  • Explanation:*

Women taking HRT had significantly lower fracture rates than those who did not, across both estrogen-only and combined regimens. - Source: [PubMed – WHI Analysis](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com) 

  RiskModel: RiskofNeverTakingHRT/Data:FractureRiskModel
    Content: 
Fracture_WithoutHRT = Fracture_WithoutHRT  
Fracture_WithHRT = Fracture_WithHRT

Cardiovascular, Stroke, and VTE Risk

<datatable2 name="CardiovascularRiskTable"> <head> Cardio_Label | Cardio_WithHRT | Cardio_WithoutHRT </head> <row> Coronary heart disease | 157 per 10,000 | 132 per 10,000 </row> <row> Stroke | 44 per 10,000 | 32 per 10,000 </row> <row> Venous thromboembolism (VTE) | 34 per 10,000 | 16 per 10,000 </row> </datatable2>

  • Explanation:*

Combined HRT was associated with small increases in cardiovascular events. - Source: [CMAJ Review](https://www.cmaj.ca/content/170/10/1535?utm_source=chatgpt.com) 

  RiskModel: RiskofNeverTakingHRT/Data:CardiovascularRiskModel
    Content: 
Cardio_WithHRT = Cardio_WithHRT[Coronary heart disease]  
Cardio_WithoutHRT = Cardio_WithoutHRT[Coronary heart disease]  


  RiskModel: RiskofNeverTakingHRT/Data:StrokeRiskModel
    Content: 
Cardio_WithHRT = Cardio_WithHRT[Stroke]  
Cardio_WithoutHRT = Cardio_WithoutHRT[Stroke]  


  RiskModel: RiskofNeverTakingHRT/Data:VTERiskModel
    Content: 
Cardio_WithHRT = Cardio_WithHRT[Venous thromboembolism (VTE)]  
Cardio_WithoutHRT = Cardio_WithoutHRT[Venous thromboembolism (VTE)]

Cancer Risk Data

<datatable2 name="CancerRiskTable"> <head> Cancer_Label | Cancer_WithHRT | Cancer_WithoutHRT </head> <row> Breast Cancer (combined HRT) | +9 to +36 per 10,000 | baseline varies </row> <row> Ovarian Cancer | ~1 extra per 1,000 users | baseline varies </row> <row> Endometrial Cancer (combined HRT) | reduced or neutral | baseline varies </row> </datatable2>

  • Explanation:*

Breast and ovarian cancer risks are slightly increased with HRT use. Combined HRT may reduce endometrial cancer risk. - Sources: 

 - [Menopause.org.au](https://www.menopause.org.au/members/ims-menopause-live/use-of-hormone-replacement-therapy-hrt-and-risk-of-breast-cancer?utm_source=chatgpt.com)  
 - [SAGE Review](https://journals.sagepub.com/doi/10.1177/2053369120957514?utm_source=chatgpt.com)

  RiskModel: RiskofNeverTakingHRT/Data:BreastCancerRiskModel
    Content: 
Cancer_WithHRT = Cancer_WithHRT[Breast Cancer (combined HRT)]  


  RiskModel: RiskofNeverTakingHRT/Data:OvarianCancerRiskModel
    Content: 
Cancer_WithHRT = Cancer_WithHRT[Ovarian Cancer]

Dementia Risk (Age ≥65)

<datatable2 name="DementiaRiskTable"> <head> Dementia_Label | Dementia_WithHRT | Dementia_WithoutHRT </head> <row> Women ≥65 using combined HRT | 11 per 1,000 | 9 per 1,000 </row> </datatable2>

  • Explanation:*

HRT started in older age (≥65) may slightly raise the risk of dementia. - Source: [WHI Memory Study – PubMed](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com) 

  RiskModel: RiskofNeverTakingHRT/Data:DementiaRiskModel
    Content: 
Dementia_WithHRT = Dementia_WithHRT  
Dementia_WithoutHRT = Dementia_WithoutHRT

Uncertainty Note

Risk estimates are population-level averages and may vary based on age, timing of HRT, genetics, and other personal health factors.

Generated by an AI assistant.

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