Data for RiskOfNeverTakingHRTForMenopause

Fracture Data

<datatable2 name="FractureRiskTable"> <head> ColumnDuration | ColumnFractureWithHRT | ColumnFractureWithoutHRT </head> <row> “7.1 years—oestrogen‑only HT: 92–113 per 1000; placebo: 141 per 1000” </row> <row> “5.6 years—combined HT: 79–96 per 1000; placebo: 111 per 1000” </row> </datatable2>

Explanation:* Long‑term HRT—either estrogen‑only or combined—was associated with lower fracture incidence compared to placebo. Estrogen‑only: fracture incidence decreased from 141 to 92–113 per 1000 over ~7.1 years; combined HT: from 111 to 79–96 per 1000 over ~5.6 years.

- Source: WHI/IARC data on HRT fracture outcomes :contentReference[oaicite:0]{index=0}.

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Cardiovascular, Stroke, and VTE Data

<datatable2 name="CardiovascularRiskTable"> <head> ColumnCondition | ColumnWithHRT | ColumnWithoutHRT </head> <row> “Estrogen‑progestin: +25 coronary events per 10 000 person‑years (157 vs 132)” </row> <row> “Estrogen‑only: +12 strokes per 10 000 person‑years” </row> <row> “Estrogen‑only: +7 thromboembolic events per 10 000 person‑years” </row> </datatable2>

Explanation:* In the estrogen‑progestin arm, coronary events increased by 25 per 10,000 person‑years. In the estrogen‑only arm, there were 12 additional strokes and 7 additional venous thromboembolic events per 10,000 person‑years.

- Source: WHI data summarized by Canadian Task Force :contentReference[oaicite:1]{index=1}.

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Breast Cancer Data

<datatable2 name="CancerRiskTable"> <head> ColumnWithHRT | ColumnExtraBreastCancerPer </head> <row> “9 additional breast cancers per 10 000 women with estrogen‑progestin for ≥5 years” </row> </datatable2>

Explanation:* Long‑term combined estrogen‑progestin HRT was associated with ~9 extra breast cancer cases per 10,000 women over 5 years.

- Source: WHI breast cancer risk data :contentReference[oaicite:2]{index=2}.

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Dementia Data

<datatable2 name="DementiaRiskTable"> <head> ColumnOutcome | ColumnWithHRT | ColumnWithoutHRT </head> <row> “Dementia (≥65 yrs, combined HT 4 yrs): 11 vs 9 per 1000” </row> </datatable2>

Explanation:* Among women aged 65 and older, combined HRT for ~4 years raised dementia incidence from 9 to 11 per 1000 per year—i.e., ~2 additional cases per 1000 per year.

- Source: WHI dementia outcomes :contentReference[oaicite:3]{index=3}.

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Uncertainty Note

Risks are based on population averages. Individual outcomes may vary depending on age, health status, type/formulation of HRT, and geographic or demographic factors.

Generated by an AI assistant.