|
|
| = Data for RiskOfNeverTakingHRTForMenopause =
| |
|
| |
|
| == Fracture Risk Data ==
| |
| <riskdata table="FractureRiskTable" columns="label|withHRT|withoutHRT">
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| <head>
| |
| ! Scenario (for dropdown)
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| ! Fractures with HRT (per 1000)
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| ! Fractures without HRT (per 1000)
| |
| </head>
| |
| 7.1 years – estrogen‑only HRT | 92–113 | 141
| |
| 5.6 years – combined HRT | 79–96 | 111
| |
| </riskdata>
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|
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| *Explanation:*
| |
| Women on HRT had fewer fractures than those not taking it—for both estrogen-only and combined regimens.
| |
| - Source: [PubMed – WHI WHR Study](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com)
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|
| |
| <RiskModel name="FractureRiskModel" calculation="withoutHRT - withHRT">
| |
| label = label
| |
| withHRT = withHRT
| |
| withoutHRT = withoutHRT
| |
| </RiskModel>
| |
|
| |
| == Cardiovascular, Stroke, and VTE Risk Data ==
| |
| <riskdata table="CardiovascularRiskTable" columns="condition|withHRT|withoutHRT">
| |
| <head>
| |
| ! Condition (for dropdown)
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| ! Incidence with HRT (per 10,000)
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| ! Incidence without HRT (per 10,000)
| |
| </head>
| |
| Coronary heart disease | 157 | 132
| |
| Stroke | 44 | 32
| |
| Venous thromboembolism (VTE) | 34 | 16
| |
| </riskdata>
| |
|
| |
| *Explanation:*
| |
| Combined HRT is associated with slightly higher incidence of CHD, stroke, and VTE.
| |
| - Source: [CMAJ WHI Summary](https://www.cmaj.ca/content/170/10/1535?utm_source=chatgpt.com)
| |
|
| |
| <RiskModel name="CHDRiskModel" calculation="withHRT - withoutHRT">
| |
| condition = 'Coronary heart disease'
| |
| withHRT = withHRT
| |
| withoutHRT = withoutHRT
| |
| </RiskModel>
| |
|
| |
| <RiskModel name="StrokeRiskModel" calculation="withHRT - withoutHRT">
| |
| condition = 'Stroke'
| |
| withHRT = withHRT
| |
| withoutHRT = withoutHRT
| |
| </RiskModel>
| |
|
| |
| <RiskModel name="VTERiskModel" calculation="withHRT - withoutHRT">
| |
| condition = 'Venous thromboembolism (VTE)'
| |
| withHRT = withHRT
| |
| withoutHRT = withoutHRT
| |
| </RiskModel>
| |
|
| |
| == Cancer Risk Data ==
| |
| <riskdata table="CancerRiskTable" columns="cancerType|withHRT|withoutHRT">
| |
| <head>
| |
| ! Cancer Type (for dropdown)
| |
| ! Incidence with HRT (per women-years)
| |
| ! Baseline without HRT
| |
| </head>
| |
| Breast Cancer (combined HRT) | +9 to +36 per 10,000 | baseline varies
| |
| Ovarian Cancer | ~1 per 1,000 | baseline varies
| |
| Endometrial Cancer (combined HRT) | reduced/neutral | baseline varies
| |
| </riskdata>
| |
|
| |
| *Explanation:*
| |
| Combined HRT may increase breast and ovarian cancer risk, but appears neutral or protective for endometrial cancer.
| |
| - Sources:
| |
| - [Menopause.org.au Breast Cancer](https://www.menopause.org.au/members/ims-menopause-live/use-of-hormone-replacement-therapy-hrt-and-risk-of-breast-cancer?utm_source=chatgpt.com)
| |
| - [SAGE Journal Analysis](https://journals.sagepub.com/doi/10.1177/2053369120957514?utm_source=chatgpt.com)
| |
|
| |
| <RiskModel name="BreastCancerRiskModel" calculation="withHRT">
| |
| cancerType = 'Breast Cancer (combined HRT)'
| |
| withHRT = withHRT
| |
| </RiskModel>
| |
|
| |
| <RiskModel name="OvarianCancerRiskModel" calculation="withHRT">
| |
| cancerType = 'Ovarian Cancer'
| |
| withHRT = withHRT
| |
| </RiskModel>
| |
|
| |
| == Dementia Risk Data ==
| |
| <riskdata table="DementiaRiskTable" columns="scenario|withHRT|withoutHRT">
| |
| <head>
| |
| ! Scenario (for dropdown)
| |
| ! Dementia incidence with HRT (per 1000)
| |
| ! Dementia incidence without HRT (per 1000)
| |
| </head>
| |
| Women ≥65, combined HRT | 11 | 9
| |
| </riskdata>
| |
|
| |
| *Explanation:*
| |
| In women aged 65+, combined HRT is tied to slightly higher dementia risk.
| |
| - Source: [WHI Memory Study – PubMed](https://pubmed.ncbi.nlm.nih.gov/28093732/?utm_source=chatgpt.com)
| |
|
| |
| <RiskModel name="DementiaRiskModel" calculation="withHRT - withoutHRT">
| |
| scenario = 'Women ≥65, combined HRT'
| |
| withHRT = withHRT
| |
| withoutHRT = withoutHRT
| |
| </RiskModel>
| |
|
| |
| == Uncertainty Note ==
| |
| These figures represent population averages and may not apply to every individual due to variables like geography, age at menopause, HRT type, and personal health.
| |
|
| |
| Generated by an AI assistant.
| |